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Evidence for zinc protection against 2,5-hexanedione toxicity by co-exposure of rats to zinc chloride

2000; Wiley; Volume: 20; Issue: 3 Linguagem: Inglês

10.1002/(sici)1099-1263(200005/06)20

1099-1263

M.L. Mateus, Ana Paula Marreilha dos Santos, M.C.C. Batoréu,

Plant Toxicity and Pharmacological Properties

Journal of Applied ToxicologyVolume 20, Issue 3 p. 211-214 Research Article Evidence for zinc protection against 2,5-hexanedione toxicity by co-exposure of rats to zinc chloride M. L. Mateus, M. L. Mateus Laboratory of Toxicology, Faculty of Pharmacy, Av das Forças Armadas, 1600 Lisbon, PortugalSearch for more papers by this authorA. P. M. Dos Santos, A. P. M. Dos Santos Laboratory of Toxicology, Faculty of Pharmacy, Av das Forças Armadas, 1600 Lisbon, PortugalSearch for more papers by this authorM. C. Batoreu, Corresponding Author M. C. Batoreu Laboratory of Toxicology, Faculty of Pharmacy, Av das Forças Armadas, 1600 Lisbon, PortugalLaboratory of Toxicology, Faculty of Pharmacy, Av das Forças Armadas, 1600 Lisbon, Portugal.Search for more papers by this author M. L. Mateus, M. L. Mateus Laboratory of Toxicology, Faculty of Pharmacy, Av das Forças Armadas, 1600 Lisbon, PortugalSearch for more papers by this authorA. P. M. Dos Santos, A. P. M. Dos Santos Laboratory of Toxicology, Faculty of Pharmacy, Av das Forças Armadas, 1600 Lisbon, PortugalSearch for more papers by this authorM. C. Batoreu, Corresponding Author M. C. Batoreu Laboratory of Toxicology, Faculty of Pharmacy, Av das Forças Armadas, 1600 Lisbon, PortugalLaboratory of Toxicology, Faculty of Pharmacy, Av das Forças Armadas, 1600 Lisbon, Portugal.Search for more papers by this author First published: 20 April 2000 https://doi.org/10.1002/(SICI)1099-1263(200005/06)20:3 3.0.CO;2-OCitations: 5AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract The protective role of zinc against the toxic effects of 2,5-hexanedione (2,5-HD), the main neurotoxic metabolite of n-hexane, was investigated by studying the interference of zinc on the toxicokinetics of 2,5-HD. Six groups of Wistar rats were exposed for 3 days to diets containing 2,5-HD, zinc chloride and 2,5-HD+zinc chloride. The amounts of pyrroles and free and total 2,5-HD in urine were determined using Ehrlichs's reagent and gas chromatography/flame ionization detection, respectively. The results show that after the first day of co-exposure (ZnCl2+2,5-HD) there was a significant decrease in the excretion of pyrroles and free 2,5-HD in rats exposed to the chemical mixture when compared to the pyrroles and free 2,5-HD excreted in rats exposed to 2,5-HD alone. However, no significant decrease was observed in the urinary excretion of total 2,5-HD (free 2,5-HD + preformed 2,5-HD). Suggestions are made about the role played by this metal ion in inhibiting pyrrole formation. Copyright © 2000 John Wiley & Sons, Ltd. Citing Literature Volume20, Issue3May/June 2000Pages 211-214 RelatedInformation