α-fetoprotein: Reevaluation in hepatology
1990; Lippincott Williams & Wilkins; Volume: 12; Issue: 6 Linguagem: Inglês
10.1002/hep.1840120625
ISSN1527-3350
Autores Tópico(s)Renal and related cancers
ResumoHepatologyVolume 12, Issue 6 p. 1420-1432 Special ArticleFree Access α-fetoprotein: Reevaluation in hepatology Dr. Kazuhisa Taketa, Corresponding Author Dr. Kazuhisa Taketa Health Research Center, Kagawa University, Takamatsu 760, JapanHealth Research Center, Kagawa University, 1–1 Saiwai-cho, Takamatsu 760, Japan===Search for more papers by this author Dr. Kazuhisa Taketa, Corresponding Author Dr. Kazuhisa Taketa Health Research Center, Kagawa University, Takamatsu 760, JapanHealth Research Center, Kagawa University, 1–1 Saiwai-cho, Takamatsu 760, Japan===Search for more papers by this author First published: December 1990 https://doi.org/10.1002/hep.1840120625Citations: 278AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Bergstrand CG, Czar B. Demonstration of new protein fraction in serum from the human fetus. Scand J Clin Lab Invest 1956; 8: 174. 2 Halbrecht I, Klibanski C. Identification of a new normal embryonic haemoglobin. Nature 1956; 178: 794–795. 3 Abelev GI, Perova SD, Khramkova NI, Postnikova ZA, Irlin IS. Production of embryonal α-globulin by transplantable mouse hepatomas. Transplant Bull 1963; 1: 174–180. 4 Tatarinov YS. The discovery of fetal globulin in patients with primary cancer of the liver [Abstract]. First International Biochemistry Congress of the USSR. Moscow: Academy of Sciences USSR, 1963: 274. 5 Tatarinov YS. Presence of embryospecific α-globulin in the serum of patients with primary hepatocellular carcinoma. Vopr Med Khim 1964; 10: 90–91. 6 Abelev GI, Assekritova IV, Kraevsky NA, Perova SD, Perevodchikova NI. Embryonal serum α-globulin in cancer patients: diagnostic value. Int J Cancer 1967; 2: 551–558. 7 Masopust J, Kithier K, Rádl J, Koutecký J, Kotál L. Occurrence of fetoprotein in patients with neoplasms and nonneoplastic diseases. Int J Cancer 1968; 3: 364–373. 8 Tatarinov YS. The past and the future for cancer testing by alpha-fetoprotein: a review. J Nucl Med Allied Sci 1989; 33 (suppl): 5–11. 9 Alpert ME, Uriel J, de Nechaud B. Alpha1 fetoglobulin in the diagnosis of human hepatoma. N Engl J Med 1968; 278: 984–986. 10 Ruoslahti E, Seppälä M. Studies of carcino-fetal proteins. III. Development of a radioimmunoassay for alpha-fetoprotein: demonstration of alpha-fetoprotein in serum of healthy human adults. Int J Cancer 1971; 8: 374–383. 11 Nishi S, Hirai H. Radioimmunoassay of α-fetoprotein in hepatoma, other liver diseases, and pregnancy. Gann Monogr Cancer Res 1973; 14: 79–87. 12 Ruoslahti E, Salaspuro M, Pihko H, Andersson L, Seppälä M. Serum alpha-fetoprotein: diagnostic significance in liver disease. Br Med J 1974; 8: 527–529. 13 Alpert E. Human alpha-1 fetoprotein. In: K Okuda, RL Peters, eds. Hepatocellular carcinoma. New York: John Wiley & Sons, 1976: 353–367. 14 Lehmann F-G, Wegener T. Alpha-fetoprotein in liver cirrhosis. I. Prognostic and diagnostic significance of the transient rise of serum alpha-fetoprotein. In: F-G Lehmann, ed. Carcinoembryonic proteins. Vol I. Amsterdam:Elsevier/North-Holland Biomedical Press, 1979: 219–231. 15 Gleiberman AS, Abelev GI. Cell position and cell interactions in expression of fetal phenotype of hepatocyte. Int Rev Cytol 1985; 95: 229–266. 16 Sawadaishi K, Morinaga T, Tamaoki T. Interaction of a hepatoma-specific nuclear factor with transcription-regulatory sequences of the human α-fetoprotein and albumin genes. Mol Cell Biol 1988; 8: 5179–5187. 17 Nakabayashi H, Watanabe K, Saito A, Otsuru A, Sawadaishi K, Tamaoki T. Transcriptional regulation of α-fetoprotein expression by dexamethasone in human hepatoma cells. J Biol Chem 1989; 264: 266–271. 18 Tamaoki T. Molecular mechanisms of up- and down-regulation of the human α-fetoprotein gene [Abstract]. J Tumor Marker Oncol 1989; 4: 161. 19 Di Bisceglie AM, Hoofnagle JH. Elevations in serum alphafetoprotein levels in patients with chronic hepatitis B. Cancer 1989; 64: 2117–2120. 20 Toukan A, Kimball K, Alpert E. Prognostic significance of alpha-fetoprotein in chronic viral hepatitis: results of a long-term follow-up study [Abstract]. Gastroenterology 1990; 98: A640. 21 Furukawa R, Tajima H, Nakata K, Kono K, Muro T, Sato A, Kawahara K, et al. Clinical significance of serum alphafetoprotein in patients with liver cirrhosis. Tumor Biol 1984; 5: 327–338. 22 Hirai H. Hepatocellular cancer. Tumor Biol 1987; 8: 86–93. 23 Bręborowicz J, Mackiewicz A, Bręborowicz D. Microheterogeneity of alpha-fetoprotein in patient serum as demonstrated by lectin affino-electrophoresis. Scand J Immunol 1981; 14: 15–20. 24 Miyazaki J, Endo Y, Oda T. Lectin affinities of alpha-fetoprotein in liver cirrhosis, hepatocellular carcinoma and metastatic liver tumor. Acta Hepatol Jpn 1981; 22: 1559–1568. 25 Hirai H. Model systems of AFP and CEA expression. Methods Cancer Res 1979; 18: 39–97. 26 Wepsic HT, Kirkpatrick A. Alpha-fetoprotein and its relevance to human disease. Gastroenterology 1979; 77: 787–796. 27 Sell S. Diagnostic applications of alpha-fetoprotein: government regulations prevent full application of a clinically useful test. Hum Pathol 1981; 12: 959–958. 28 GJ Mizejewski, HI Jacobson, eds. Biological activities of alpha1fetoprotein. Vol II. Boca Raton, Fla: CRC Press, 1987: 1–262. 29 GJ Mizejewski, HI Jacobson, eds. Biological activities of alpha1fetoprotein. Vol II. Boca Raton, Fla: CRC Press, 1989: 1–288. 30 Abelev GI. Alpha-fetoprotein: 25 years of study. Tumor Biol 1989; 10: 63–74. 31 Pecchio F, Rapellino M, Torre GC, eds. International workshop on alpha-fetoprotein: new trends and perspectives. J Nucl Med Allied Sci 1989; 33 (suppl): 1–137. 32 Morinaga T, Sakai M, Wegmann TG, Tamaoki T. Primary structures of human α-fetoprotein and its mRNA. Proc Natl Acad Sci USA 1983; 80: 4604–4608. 33 Gibbs PEM, Zielinski R, Boyd C, Dugaiczyk A. Structure, polymorphism and novel repeated DNA elements revealed by a complete structure of the human α-fetoprotein gene. Biochemistry 1987; 26: 1332–1343. 34 Nunez EA, Vallette G, Benassayag C, Jayle M-F. Comparative study on the binding of estrogens by human and rat serum proteins in development. Biochem Biophys Res Commun 1974; 57: 126–133. 35 Yang F, Brune JL, Naylor SL, Cupples RL, Naberhauts KH, Bowman BH. Human group-specific component (Gc) is a member of the albumin family. Proc Natl Acad Sci USA 1985; 82: 7994–7998. 36 Cooke NE, David EV. Serum vitamin D—binding protein is a third member of the albumin and alpha fetoprotein gene family. J Clin Invest 1985; 76: 2420–2424. 37 Nakabayashi H, Taketa K, Miyano K, Yamane T, Sato J. Growth of human hepatoma cell lines with differentiated functions in chemically defined medium. Cancer Res 1982; 42: 3858–3863. 38 Egawa T, Yamamoto H, Kishimoto S. Vitamin D—binding protein synthesized by a human hepatocellular carcinoma cell line. Clin Chim Acta 1987; 167: 273–284. 39 Parmelee DC, Evenson MA, Deutsch HF. The presence of fatty acids in human α-fetoprotein. J Biol Chem 1978; 253: 2114–2119. 40 Villacampa MJ, Moro R, Naval J, Failly-Crepin C, Lampreave F, Uriel J. Alpha-fetoprotein receptors in a human breast cancer cell line. Biochem Biophys Res Commun 1984; 122: 1322–1327. 41 Geuskens M, Naval J, Uriel J. Ultrastructural studies of the intracellular translocation of endocytosed alpha-fetoprotein (AFP) by cytochemistry and of the uptake of 3H-arachidonic acid bound to AFP by autoradiography in rat rhabdomyosarcoma cells. J Cell Physiol 1986; 128: 389–396. 42 Hasegawa H, Mukojima T, Hattori N, Sano R, Hirota T. Embryonal carcinoma and α-fetoprotein with special reference to hepatoblastoma. Gann Monogr Cancer Res 1973; 14: 129–139. 43 Murgita R, Tomasi T. Suppression of the immune response by α-fetoprotein. J Exp Med 1975; 141: 269–286. 44 Yachnin S, Gets GS, Lusk L, Hsu RC. Lipid interactions with human alpha-fetoprotein (AFP): a study of the role of such interactions in the ability of human AFP to suppress lymphocyte transformation. Oncodev Biol Med 1980; 1: 273–285. 45 Masseyeff R, Bonet C, Drouet J, Sudaka P, Lalanne C. Radioimmunoassay of α-fetoprotein. I. Technique and serum levels in the normal adult. Digestion 1974; 10: 17–28. 46 Chayvialle JAP, Barissot P, Pelletier MJ, Hita de Nercy Y, Lambert R, Bourel M. α-Fetoprotein screening in patients with idiopathic hemochromatosis and liver cirrhosis. Digestion 1977; 16: 118–127. 47 Out TA, Wegman CMM, Nieuwenhuys EJ, Bruning PF, Bonfrer JMG, Nooijen WJ. Monitoring very low levels of AFP in the early detection of tumor recurrency. In: H Peeters, ed. Protides of the biological fluids, XXXI. Oxford: Pergamon Press, 1984: 395–398. 48 Ball D, Rose E, Alpert E. Biological variation of alpha-fetoprotein levels in normal adults [Abstract]. Gastroenterology 1990; 98: A271. 49 Sato Y, Une Y, Hata Y, Uchino J, Kasai Y, Nishi S. Development of AFP radioimmunoassay with monoclonal antibodies and its clinical evaluation. Acta Hepatol Jpn 1984; 25: 231–234. 50 Tsuchida Y, Endo Y, Saito S, Kaneko M, Shiraki K, Ohmi K. Evaluation of alpha-fetoprotein in early infancy. J Pediatr Surg 1978; 13: 155–156. 51 Ferguson-Smith MA, May HM, O'Hare E, Aitken DA. Hereditary persistence of alphafetoprotein: a new autosomal dominant trait identified in the antenatal screening programme for spina bifida [Abstract]. J Med Genet 1983; 20: 458. 52 Ferguson-Smith MA, Yates JRW, Kelly D, Aitken DA, May HM, Krumlauf R, Tilghman SM. Hereditary persistence of alphafetoprotein maps to the long arm of chromosome 4 [Abstract]. Cytogenet Cell Genet 1985; 40: 628. 53 Greenberg F, Rose E, Alpert E. Hereditary persistence of alpha-fetoprotein. Gastroenterology 1990; 98: 1083–1085. 54 Chandra RK, Madhavankutty K, Way RC. Serum α-fetoprotein levels in patients with cystic fibrosis and their parents and siblings. Br Med J 1975; 29: 714–716. 55 Okimoto Y, Fujihara T, Tsuda M, Kinoshita M, Takaoka M, Uchida Y, Fukuda Y, et al. An extremely rare adult case with high alpha-fetoprotein in serum and with normal liver cells stained partially with alpha-fetoprotein. Jpn J Gastroenterol 1989; 86: 2812–2815. 56 Silver HKB, Deneault J, Gold P, Thompson WG, Shuster J, Freedman SO. The detection of α1-fetoprotein in patients with viral hepatitis. Cancer Res 1974; 34: 244–247. 57 Chen DS, Sung JL. Serum alphafetoprotein in hepatocellular carcinoma. Cancer 1977; 40: 779–783. 58 Alpert E, Feller ER. α-Fetoprotein (AFP) in benign liver disease: evidence that normal liver regeneration does not induce AFP synthesis. Gastroenterology 1978; 74: 856–858. 59 Chen DS, Sung JL. Relationship of hepatitis B surface antigen to serum α-fetoprotein in nonmalignant diseases of the liver. Cancer 1979; 44: 984–992. 60 Sugimoto M, Itsukaichi T, Ishii K, Sumino Y, Sugano S, Abei T, Imamura Y. Marked increase in serum α-fetoprotein level in cirrhosis: a case report. Am J Gastroenterol 1987; 82: 69–71. 61 Liaw YF, Tai DI, Chu CM, Pao CC, Chen TJ. Acute exacerbation in chronic type B hepatitis: comparison between HBeAg and antibody-positive patients. Hepatology 1987; 7: 20–23. 62 Karvountzis GG, Redeker AG. Relation of alpha-fetoprotein in acute hepatitis to severity and prognosis. Ann Intern Med 1974; 80: 156–160. 63 Bloomer JR, Waldmann TA, McIntire KR, Klatskin G. Serum α-fetoprotein in patients with massive hepatic necrosis. Gastroenterology 1977; 72: 479–482. 64 Bloomer JR, Waldmann TA, McIntire KR, Klatskin G. α-Fetoprotein in nonneoplastic hepatic disorders. JAMA 1975; 233: 38–41. 65 Bergmann J-F, Lang F, Dechy H, Dorra M. α-Fetoprotein in hepatitis superimposed on cirrhosis: a case of concomitant hepatitis B surface antigen and antibody associated with a major but transient increase in the α-fetoprotein level. Am J Gastroenterol 1985; 80: 810–812. 66 Francioni S, Pastore M. Alpha-fetoprotein and acute viral hepatitis type B. J Nucl Med Allied Sci 1989; 33 (suppl): 103–106. 67 Liaw YF, Tai DI, Chen TJ, Chu CM, Huang MJ. Alphafetoprotein changes in the course of chronic hepatitis: relation to bridging hepatic necrosis and hepatocellular carcinoma. Liver 1986; 6: 133–137. 68 Ebara M, Ohto M, Shinagawa T, Sugiura N, Kimura K, Matsutani S, Morita M, et al. Natural history of minute hepatocellular carcinoma smaller than three centimeters complicating cirrhosis: a study in 22 patients. Gastroenterology 1986; 90: 289–298. 69 Sheu JC, Sung JL, Chen DS, Yang PM, Lai MY, Lee CS, Hsu HC, et al. Growth rate of asymptomatic hepatocellular carcinoma and its clinical implications. Gastroenterology 1985; 89: 259–266. 70 Chen DS, Sung JL, Sheu JC, Lai MY, How SW, Hsu HC, Lee CS, et al. Serum α-fetoprotein in the early stage of human hepatocellular carcinoma. Gastroenterology 1984; 86: 1404–1409. 71 Bélanger L, Bélanger M, Prive L, Larochelle J, Tremblay M, Aubin G, Tyrosinémie héréditaire et alpha-1-foetoprotéine. I. Intérét clinique de l'alpha-foeto-protéine dans la tyrosinémie héréditaire. Pathol Biol (Paris) 1973; 21: 449–455. 72 Waldmann TA, McIntire KE. Serum alpha-fetoprotein levels in patients with ataxia-telangiectasia. Lancet 1972; 2: 1112–1115. 73 Nomura F, Ohnishi K, Tanabe Y. Clinical features and prognosis of hepatocellular carcinoma with reference to serum alphafetoprotein levels. Cancer 1989; 64: 1700–1707. 74 Liver Cancer Study Group of Japan. Primary liver cancer in Japan: sixth report. Cancer 1987; 60: 1400–1411. 75 Liver Cancer Study Group of Japan. Survey and follow-up study of primary liver cancer in Japan: report 8. Acta Hepatol Jpn 1988; 29: 1619–1626. 76 Taketa K. AFP. J Med Technol 1989; 33: 1380–1384. 77 Shinagawa T, Ohto M, Kimura K, Tsunetomi S, Morita M, Saisho H, Tsuchiya Y, et al. Diagnosis and clinical features of small hepatocellular carcinoma with emphasis on the utility of realtime ultrasonography: a study in 51 patients. Gastroenterology 1984; 86: 495–502. 78 Sonoda K, Shirabe K, Takenaka K, Kanematsu T, Yasumori K, Sugimachi K. Angiographically undetected small hepatocellular carcinoma: clinicopathological characteristics, follow-up and treatment. Hepatology 1989; 10: 1003–1007. 79 Okuda K. Early recognition of hepatocellular carcinoma. Hepatology 1986; 6: 729–738. 80 Kondo F, Wada K, Nagato Y, Nakajima T, Kondo Y, Hirooka N, Ebara M, et al. Biopsy diagnosis of well-differentiated hepatocellular carcinoma based on new morphologic criteria. Hepatology 1989; 9: 751–755. 81 Brumm C, Schulze C, Charels K, Morohoshi T, Klöppel G. The significance of alpha-fetoprotein and other tumor markers in differential immunocytochemistry of primary liver tumors. Histopathology 1989; 14: 503–513. 82 Okuda K, Nakashima T, Kojiro M, Kondo Y, Wada K. Hepatocellular carcinoma without cirrhosis in Japanese patients. Gastroenterology 1989; 97: 140–146. 83 Paradinas FJ, Melia WM, Wilkinson ML, Portmann B, Johnson PJ, Murray-Lyon IM, William R. High serum B12 binding capacity as a marker of the fibrolamellar variant of hepatocellular carcinoma. Br Med J 1982; 285: 840–842. 84 Akai S, Kato K. Serum alpha-fetoprotein positive stomach cancer. Gann Monogr Cancer Res 1973; 14: 149–154. 85 Waldmann TA, McIntire KR. The use of a radioimmunoassay for alpha-fetoprotein in the diagnosis of malignancy. Cancer 1974; 34: 1510–1515. 86 McIntire KR, Waldmann TA, Woertel CG, Go VLW. Serum α-fetoprotein in patients with neoplasms of the gastrointestinal tract. Cancer Res 1975; 35: 991–996. 87 Murakami Y, Ohhigashi S, Kohmo N, Nakai S, Kado S, Masuda T, Kohama Y, et al. A case of α-fetoprotein (AFP)-producing gastric cancer: the review of 114 cases of AFP-producing gastric cancer in Japan. J Hiroshima Med Assoc 1985; 38: 1204–1212. 88 Ishikura H, Kirimoto K, Shamoto M, Miyamoto Y, Yamagiwa H, Itoh T, Aizawa M. Hepatoid adenocarcinomas of the stomach: an analysis of seven cases. Cancer 1986; 58: 119–126. 89 Trojan J, Uriel J. Immunocytochemical localization of alphafetoprotein (AFP) and serum albumin (Alb) in ecto-, meso- and endodermal derivative of the developing rat. Oncodev Biol Med 1982; 3: 12–22. 90 Mackiewicz A, Brçborowicz J. The in vitro production of alpha-fetoprotein variants by human fetal organs. Oncodev Biol Med 1980; 1: 251–261. 91 Taketa K, Ichikawa E, Sakuda H, Iwamasa T, Hayakawa M, Taga H, Hirai H. Lectin reactivity of alpha-fetoprotein in a case of renal cell carcinoma. Tumor Biol 1989; 10: 275–280. 92 Sarcione EJ, Hart D. Biosynthesis of alpha-fetoprotein by MCF7 human breast cancer cells. Int J Cancer 1985; 315–319. 93 Sarcione EJ, Biddle W. Elevated serum alpha fetoprotein levels in postmenopausal women with primary breast carcinoma. Dis Markers 1987; 5: 75–79. 94 Mihalev A, Tzingilev D, Sirakov LM. Radioimmunoassay of alpha-fetoprotein in the serum of patients with leukemia and malignant melanoma. Neoplasma 1978; 23: 103–107. 95 Wyscocki M, Domaniewski J, Cetnarowski AB-BL, Czerwionka-Szaflarska M, Sujkowska R. Carcinoembryonic antigen, alphafetoprotein and alpha and beta subunits of human chorionic gonadotropin in plasma of children with acute leukemia. Acta Paediatr Hung 1987; 28: 119–125. 96 Koji T, Ishii N, Munehisa T, Kusumoto Y, Nakamura S, Tamenishi A, Hara A, et al. Localization of radioiodinated antibody to α-fetoprotein in hepatoma transplanted in rats and a case report of α-fetoprotein antibody treatment of a hepatoma patient. Cancer Res 1980; 40: 3013–3015. 97 Goldenberg DM, Kim E, Deland F, Spremulli E, Nelson MO, Gockrman JP, Primus FJ. Clinical studies on the radioimmunodetection of tumors containing alpha-fetoprotein. Cancer 1980; 45: 2500–2502. 98 Springolo E, Kew MC, Esser J, Beyers M, Conradie JD, Levin J. The use of a monoclonal antibody against α-fetoprotein for the radioimmunodetection of hepatocellular carcinoma. Hepatology 1989; 9: 116–120. 99 Galun E, Shouval D, Adler R, Shahaar M, Wilchek M, Hurwitz E, Sela M. The effect of anti-α-fetoprotein-adriamycin conjugate on a human hepatoma. Hepatology 1990; 11: 578–584. 100 Moro R, Heuguerot C, Vercelli-Retta J, Fielitz W, Lopez JJ, Roca R. The use of radioiodinated alpha-fetoprotein for the scintigraphic detection of mouse mammary carcinomas. Nucl Med Commun 1984; 5: 5–12. 101 Abelev GI. Alpha-fetoprotein in ontogenesis and its association with malignant tumors. Adv Cancer Res 1971; 14: 295–357. 102 Taketa K, Watanabe A, Kosaka K. Different mechanisms of increased α-fetoprotein production in rats following CCl4 intoxication and partial hepatectomy. Ann NY Acad Sci 1975; 259: 80–84. 103 Watanabe A, Miyazaki M, Taketa K. Differential mechanisms of increased α1-fetoprotein production in rats following carbon tetrachloride injury and partial hepatectomy. Cancer Res 1976; 36: 2171–2175. 104 Watanabe A, Miyazaki M, Taketa K. Prompt elevation of rat serum α-fetoprotein by acute liver injury following a single injection of ethionine. Int J Cancer 1976; 17: 518–524. 105 Watanabe A, Miyazaki M, Taketa K. Mechanisms of increased α1-fetoprotein production in hepatic injury. Experientia 1976; 32: 470–471. 106 Sell S, Reynolds RD, Reutter W. Rat alpha1-fetoprotein: appearance after galactosamine-induced liver injury. J Natl Cancer Inst 1974; 53: 289–291. 107 Sell S, Stillman D, Gochman N. Serum alpha-fetoprotein: a prognostic indicator of liver-cell necrosis and regeneration following experimental injury by galactosamine in rats. Am J Clin Pathol 1976; 66: 847–853. 108 Nagasue N, Inokuchi K, Kobayashi M, Kanashima R. Serum alphafetoprotein in patients following partial hepatectomy. Dig Dis Sci 1980; 25: 243–247. 109 Taketa K, Shimamura J, Ueda M, Shimada Y, Kosaka K. Profiles of carbohydrate-metabolizing enzymes in human hepatocellular carcinomas and preneoplastic livers. Cancer Res 1988; 48: 467–474. 110 Tokiwa T, Taketa K, Sato J. Production of albumin and α-fetoprotein in primary culture of fetal human liver cells on collagenous substrata in the presence of hydrocortisone. In Vitro 1987; 23: 830–836. 111 Forrester PI, Hancock RL. Theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins. I. Alpha-fetoprotein induction by ethionine. Med Hypotheses 1978; 4: 31–36. 112 Locker J, Hutt S, Lombardi B. α-Fetoprotein gene methylation and hepatocarcinogenesis in rats fed a choline-devoid diet. Carcinogenesis 1987; 8: 241–246. 113 Nahon J-L, Tratner I, Poliard A, Presse F, Poiret M, Gal A, Sala-Trepat JM. Albumin and α-fetoprotein gene expression in various nonhepatic rat tissues. J Biol Chem 1988; 263: 11436–11442. 114 Nowell PC. The clonal evolution of tumor cell populations. Science 1976; 194: 23–28. 115 Nakabayashi H, Taketa K, Yamane T, Oda M, Sato J. Hormonal control of α-fetoprotein secretion in human hepatoma cell lines proliferating in chemically defined medium. Cancer Res 1985; 45: 6379–6383. 116 Di Bisceglee AM, Dusheiko GM, Paterson AC, Alexander J, Shuvar D, Lee C—S, Veasley RP, et al. Detection of alphafetoprotein messenger RNA in human hepatocellular carcinoma and hepatoblastoma tissue. Br J Cancer 1986; 54: 779–785. 117 Otsuru A, Nagataki S, Koji T, Tamaoki T. Analysis of alphafetoprotein gene expression in hepatocellular carcinoma and liver cirrhosis by in situ hybridization. Cancer 1988; 62: 1105–1112. 118 Alpert E, Drysdale JW, Isselbacher KJ, Schur PH. Human alpha-fetoprotein: isolation, characterization, and demonstration of microheterogeneity. J Biol Chem 1972; 247: 3792–3798. 119 Lester EP, Miller JB, Baron JM, Yachnin S. Inhibition of human lymphocyte transformation by human alpha-fetoprotein (HAFP): studies on the mode of HAFP action and the role of HAFP polymorphism. Immunology 1978; 34: 189–198. 120 Lester EP, Miller JB, Yachnin S. Heterogeneity of human alpha-fetoprotein as revealed by isoelectric focusing in ureacontaining gels. Biochim Biophys Acta 1978; 536: 165–171. 121 Purves LR, van der Merve E, Bersohn I. Variants of alphafetoprotein. Lancet 1070; 2: 464–465. 122 Toftager-Larsen K. Comparability of carbohydrate heterogeneity patterns of human alpha-fetoprotein in different biological fluids. In: TC Bøg-Hansen, ed. Lectins: biology—biochemistry—clinical biochemistry. Vol II. Berlin: Walter de Gruyter, 1982; 433–444. 123 Smith CJ, Kelleher PC. α1-Fetoprotein: separation of two molecular variants by affinity chromatography with concanavalin A-agarose. Biochim Biophys Acta 1973; 317: 231–235. 124 Bøg-Hansen TC, Bjerrum OJ, Ramlau J. Detection of biospecific interaction during the first dimension electrophoresis in crossed immunoelectrophoresis. Scand J Immunol 1975; 4 (suppl): 141–147. 125 Kerckaert J-P, Bayard B, Biserte G. Microheterogeneity of rat, mouse and human α1-fetoprotein as revealed by polyacrylamide gel electrophoresis and by crossed immuno-affinoelectrophoresis with different lectins. Biochim Biophys Acta 1979; 576: 99–108. 126 Buamah PK, Harris R, James OFW, Skillen AW. Lentil-lectinreactive alpha-fetoprotein in the differential diagnosis of benign and malignant liver disease. Clin Chem 1986; 32: 2083–2084. 127 Chan DW, Miao YC. Affinity chromatographic separation of alpha-fetoprotein variants: development of a mini-column procedure, and application to cancer patients. Clin Chem 1986; 32: 2143–2146. 128 Aoyagi Y, Suzuki Y, Isemura M, Soga K, Ozaki T, Ichida T, Inoue K, et al. Differential reactivity of α-fetoprotein with lectins and evaluation of its usefulness in the diagnosis of hepatocellular carcinoma. Gann 1984; 75: 809–815. 129 Toftager-Larsen K. Carbohydrate microheterogeneity of maternal serum AFP in pregnancy. In: J Hau, ed. Pregnancy proteins in animals. Berlin: Walter de Gruyter, 1986; 41–47. 130 Taketa K, Ichikawa E, Taga H, Hirai H. Antibody-affinity blotting, a sensitive technique for the detection of α-fetoprotein separated by lectin affinity electrophoresis in agarose gels. Electrophoresis 1985; 6: 492–497. 131 Taketa K. A tetrazolium method for peroxidase staining: application to the antibody-affinity blotting of α-fetoprotein separated by lectin affinity electrophoresis. Electrophoresis 1987; 8: 409–414. 132 Taketa K, Hirai H. Lectin affinity electrophoresis of α-fetoprotein in cancer diagnosis. Electrophoresis 1989; 10: 562–567. 133 Kinoshita N, Suzuki S, Matsuda Y, Taniguchi N. α-Fetoprotein antibody-lectin enzyme immunoassay to characterize sugar chains for the study of liver diseases. Clin Chim Acta 1989; 179: 143–152. 134 Feizi T. Carbohydrate differentiation antigens recognized by monoclonal antibodies. Biochem Soc Transactions 1983; 11: 263–265. 135 Kitagawa H, Ohkouchi E, Hata J, Tsuchida Y, Fukuda A, Tada T. Monoclonal antibodies with fine specificities distinguishing alpha-fetoproteins of hepatoma and yolk sac tumor origin. Jpn J Cancer Res 1986; 77: 1012–1017. 136 Suzuki Y, Aoyagi Y, Muramatsu M, Sekine C, Isemura M, Ichida F. Close topographical relationship in alpha foetoprotein (AFP) between a Lens culinaris binding glycan and the epitope recognized by AFP-reactive monoclonal antibody, 18H4. Br J Cancer 1987; 55: 147–152. 137 Sittenfeld A, Moreno E. A sensitive blotting system for detection of α-fetoprotein variants with monoclonal and polyclonal antibodies. J Immunol Methods 1988; 106: 19–26. 138 Suzuki Y, Aoyagi Y, Muramatsu M, Igarashi K, Saito A, Oguro M, Isemura M, et al. A lectin-based monoclonal enzyme immunoassay to distinguish fucosylated and non-fucosylated α-fetoprotein molecular variants. Ann Clin Biochem 1990; 27: 121–128. 139 Taketa K, Ichikawa E, Umetsu K, Suzuki T. Allomyrina dichotoma lectin-nonreactive α-fetoprotein in hepatocellular carcinoma and other tumors: comparison with Ricinus communis agglutinin-I. Cancer Lett 1986; 31: 325–331. 140 Taketa K, Ichikawa E, Umetsu K, Suzuki T, Taga H, Hirai H. Differential tumor specificities of asialo-α-fetoproteins separated by affinity electrophoresis with E-PHA and allo A lectins. J Tumor Marker Oncol 1987; 2: 133–139. 141 Ruoslahti E, Engvall E, Pekkala A, Seppälä M. Developmental changes in carbohydrate moiety of human alpha-fetoprotein. Int J Cancer 1978; 22: 515–520. 142 Smith CJ, Ajdukiewicz A, Kelleher PC. Concanavalin-A-affinity molecular heterogeneity of human hepatoma AFP and cordserum AFP. Ann N Y Acad Sci 1983; 417: 69–74. 143 Ishiguro T, Sawada M, Sakaguchi H, Sugitachi I. Alphafetoprotein subfractions in germ cell tumors identified by Con A or LCH crossed-line affinity immunoelectrophoresis. Am J Reprod Immunol 1984; 5: 102–105. 144 Buamah PK, Gibb I, Bates G, Ward AM. Serum alpha fetoprotein heterogeneity as a means of differentiating between primary hepatocellular carcinoma and hepatic secondaries. Clin Chim Acta 1984; 139: 313–316. 145 Mackiewicz A, Jakubek P, Sajdak S, Brçborowicz J. Microheterogeneity forms of alpha-fetoprotein present in amniotic fluid. Placenta 1984; 5: 373–380. 146 Taketa K, Sekiya C, Namiki M, Akamatsu K, Ohta Y, Endo Y, Kosaka K. Lectin-reactive profiles of alpha-fetoprotein characterizing hepatocellular carcinoma and related conditions. Gastroenterology 1990; 99: 508–518. 147 Tsuchida Y, Fukui M, Sakaguchi H, Ishiguro T. Analysis of lectin affinity immunoelectrophoretic profiles of serum alphafetoprotein from patients with yolk sac tumors and carcinomas of the gastrointestinal tract: correlation with molecular structures. Tumor Biol 1989; 10: 289–296. 148 Ishiguro T, Sakaguchi H, Fukui M, Sugitachi I. Serum alphafetoprotein subfractions in hepatic malignancies identified by different reactivities with concanavalin A, lentil lectin or phytohemagglutinin-E. Jpn J Surg 1986; 16: 16–21. 149 Yoshimoto T, Higashino K, Hada T, Tamura S, Nakanishi K, Mitsunobu M, Uematsu K, et al. A primary lung carcinoma producing alpha-fetoprotein, carcinoembryonic antigen, and human chorionic gonadotropin. Cancer 1987; 60: 2744–2750. 150 Taketa K, Ichikawa E, Izumi M. Three-dimensional crossed immunoelectrophoresis for two-dimensional lectin affinity electrophoresis of human α-fetoprotein. In: V Neuhoff, ed. Electrophoresis '84. Veinheim: Verlag Chemie, 1984; 137–140. 151 Taketa K, Ichikawa E, Nakabayashi H, Sato J, Kato K, Akai S, Ohkawa R, et al. Further resolution of human α-fetoprotein by affinity electrophoresis with erythroagglutinating phytohemagglutinin of Phaseolus vulgaris lectin. Tumor Biol 1985; 6: 519–531. 152 Ishiguro T, Sakaguchi H, Fukui M, Sugitachi I. Alphafetoprotein subfractions in amniotic fluid identified by a modification of the method of concanavalin A, lentil lectin or phytohemagglutinin-E affinity crossed-line immunoelectrophoresis. Tumor Biol 1985; 6: 195–205. 153 Taketa K, Ichikawa E, Yamamoto T, Kato H, Matsuura S, Taga H, Hirai H. Datura stramonium agglutinin-reactive α-fetoprotein isoforms in hepatocellular carcinoma and other tumors. Tumor Biol 1990; 11: 220–228. 154 Ishiguro T, Takahashi Y. Serum alpha-fetoprotein subfractions identified by Ricinus communis agglutinin I in hepatic malignancies, yolk sac tumor, benign hepatic diseases, and fetal stage. Dis Markers 1989; 7: 239–245. 155 Tsuchida Y, Kaneko M, Fukui M, Sakaguchi H, Ishiguro T. Three different types of alpha-fetoprotein in the diagnosis of malignant solid tumours: use of a sensitive lectin-affinity immunoelectrophoresis. J Pediatr Surg 1989; 24: 350–355. 156 Taketa K, Ichikawa E, Sato J, Taga H, Hirai H. Two-dimensional lectin affinity electrophoresis of α-fetoprotein: characterization of erythroagglutinating phytohemagglutinin-dependent microheterogeneity forms. Electrophoresis 1989; 10: 825–829. 157 Ishiguro T, Taketa K, Gatti RA. Tissue of origin of elevated alpha-fetoprotein in ataxia-telangiectasia. Dis Markers 1986; 4: 293–297. 158 Smith CJP, Kelleher PC. AFP carbohydrate heterogeneity as a marker for premalignancy and malignancy. In: GJ Mizejewski, HI Jacobson, eds. Biological activities of alpha1-fetoprotein. Vol. 2. Boca Raton, Fla: CRC Press, 1989; 35–43. 159 Yoshima H, Mizuochi T, Ishii M, Kobata A. Structure of the asparagine-linked sugar chains of α-fetoprotein purified from human ascites fluid. Cancer Res 1980; 40: 4276–4281. 160 Yamashita K, Hitoi A, Tsuchida Y, Nishi S, Kobata A. Sugar chain of α-fetoprotein produced in human yolk sac tumor. Cancer Res 1983; 43: 4691–4695. 161 Ogata S, Muramatsu T, Kobata A. Fractionation of glycopeptides by affinity column chromatography on concanavalin A-sepharose. J Biochem (Tokyo) 1975; 78: 678–696. 162 Yamashita K, Hitoi A, Kobata A. Structural determinants of Phaseolus vulgaris erythroagglutinating lectin for oligosaccharides. J Biol Chem 1983; 258: 14753–14755. 163 Aoyagi Y, Isemura M, Yosizawa Z, Suzuki Y, Sekine C, Ono T, Ichida F. Fucosylation of serum α-fetoprotein in patients with primary hepatocellular carcinoma. Biochim Biophys Acta 1985; 830: 217–223. 164 Kornfeld K, Reitman ML, Kornfeld R. The carbohydrate-binding specificity of pea and lentil lectins: fucose is an important determinant. J Biol Chem 1981; 256: 6633–6640. 165 Mackiewicz A, Brçborowicz J. Three-dimensional affinity electrophoresis of human alpha-fetoprotein. In: TC Bøg-Hansen, ed. Lectins: biology—biochemistry– clinical biochemistry. Vol I. Berlin: Walter de Gruyter, 1981; 315–326. 166 Yamashita K, Umetsu K, Suzuki T, Iwaki Y, Endo T, Kobata A. Carbohydrate binding specificity of immobilized Allomyrina dichotoma lectin II. J Biol Chem 1988; 263: 17482–17489. 167 Yamashita K, Totani K, Ohkura T, Takasaki S, Goldstein IJ, Kobata A. Carbohydrate binding properties of complex-type oligosaccharides on immobilized Datura stramonium lectin. J Biol Chem 1987; 262: 1602–1607. 168 Aoyagi Y, Suzuki Y, Isemura M, Nomoto M, Sekine C, Igarashi K, Ichida F. The fucosylation index of alpha-fetoprotein and its usefulness in early diagnosis of hepatocellular carcinoma. Cancer 1988; 61: 769–774. 169 Taga H, Hirai H, Ishizuka H, Kaneda H. Early diagnosis of hepatocellular carcinoma with lectin electrophoresis of serum alpha-fetoprotein. Tumor Biol 1988; 9: 110–115. 170 Asaka M, Nagase K, Miyazaki T, Alpert E. Aldolase A isozyme levels in serum and tissues of patients with liver diseases. Gastroenterology 1983; 84: 155–160. 171 Mackiewicz A, Schultz D, Mathison J, Ganapathi M, Kushner I. Effect of cytokines on glycosylation of acute phase proteins in human hepatoma cell lines. Clin Exp Immunol 1989; 75: 70–75. 172 Moriwaki Y, Higashino K, Taketa K, Hada T, Tamura S, Yamaguchi K. Immunohistochemical and affinity electrophoretic studies of α-fetoprotein of a patient with hepatocellular carcinoma in the intrathoracic space. Am J Gastroenterol 1987; 82: 1207–1211. 173 Toki A, Todani T, Watanabe Y, Urushihara N, Sato Y, Taketa K. Retroperitoneal immature teratoma producing alpha-fetoprotein. Z Kinderchir 1989; 44: 246–248. 174 Wu JT. Serum alpha-fetoprotein and its lectin reactivity in liver diseases: a review. Ann Clin Lab Sci 1990; 20: 98–105. Citing Literature Volume12, Issue6December 1990Pages 1420-1432 ReferencesRelatedInformation
Referência(s)