A multisubunit complex containing the SWI1/ADR6,SWI2/SNF2, SWI3, SNF5, and SNF6 gene products isolated fromyeast.
1994; National Academy of Sciences; Volume: 91; Issue: 5 Linguagem: Inglês
10.1073/pnas.91.5.1950
ISSN1091-6490
AutoresBradley R. Cairns, Yeon‐Jeong Kim, Michael H. Sayre, Brehon C. Laurent, Roger D. Kornberg,
Tópico(s)Cancer Mechanisms and Therapy
ResumoA complex containing the products of the SWI1/ADR6, SWI2/SNF2, SWI3, SNF5, and SNF6 genes and four additional polypeptides has been purified from extracts of the yeast Saccharomyces cerevisiae. Physical association of these proteins was demonstrated by copurification and coimmunoprecipitation. A potent DNA-dependent ATPase copurified with the complex, and this activity was evidently associated with SWI2/SNF2.
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