Immune response‐mediated pathology in human intestinal parasitic infection
2003; Wiley; Volume: 25; Issue: 5 Linguagem: Inglês
10.1046/j.1365-3024.2003.00633.x
ISSN1365-3024
Autores Tópico(s)Amoebic Infections and Treatments
ResumoParasite ImmunologyVolume 25, Issue 5 p. 247-257 Immune response-mediated pathology in human intestinal parasitic infection Michael J. G. Farthing, Corresponding Author Michael J. G. Farthing Faculty of Medicine, University of Glasgow, Glasgow, UKProfessor MJG Farthing DSc (Med), FmedSci, Wolfson Medical School Building, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK (e-mail: [email protected]).Search for more papers by this author Michael J. G. Farthing, Corresponding Author Michael J. G. Farthing Faculty of Medicine, University of Glasgow, Glasgow, UKProfessor MJG Farthing DSc (Med), FmedSci, Wolfson Medical School Building, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK (e-mail: [email protected]).Search for more papers by this author First published: 09 September 2003 https://doi.org/10.1046/j.1365-3024.2003.00633.xCitations: 17Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 Dobell CA. The discovery of intestinal protozoa in man. Proc R Soc Med, 1920; 13: 1. 2 Fox JG, Beck P, Dangler CA et al. Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces helicobacter-induced gastric atrophy. Nature Med, 2000; 6: 536–542. 3 Farthing MJG et al. Natural history of Giardia infection of infants and young children in rural Guatemala and its impact on physical growth. Am J Clin Nutr, 1986; 4: 393–403. 4 Farthing MJG, Kelly MP & Veitch AM. Recently recognised microbial enteropathies in HIV infection. J Antimicrob Chemother, 1996; 37 (Suppl. B): 61–70. 5 Hoge CW, Shlim DR, Ghimire M et al. Placebo-controlled trial of co-trimoxazole for cyclospora infections among travellers and foreign residents in Nepal. Lancet, 1995; 345: 691–693. 6 Farthing MJG. In Cryptosporidiosis and Microsporidiosis, ed. Petry F. Contrib Microbiol, Basel: Karger; 2000; 6: 50–74. 7 Carr A, Mariott D, Field A Vasak E & Cooper DA. Treatment of HIV-1-associated microsporidiosis and cryptosporidiosis with combination antiretroviral therapy. Lancet, 1998; 351: 256–261. 8 Foudraine NA, Weverling GJ, Van Gool T et al. Improvement of chronic diarrhoea in patients with advanced HIV-1 infection during potent antiretroviral therapy. AIDS, 1998; 12: 35–41. 9 Le Moing V, Bissuel F, Costagliola D et al. Decreased prevalence of intestinal cryptosporidiosis in HIV-infected patients concomitant to the widespread use of protease inhibitors. AIDS, 1998; 12: 1395–1397. 10 Kelly MP, McPhail G, Ngwenya B et al. Septata intestinalis: a new microsporidian in Africa. Lancet, 1994; 344: 271–272. 11 Batman PA, Fleming SC, Sedgwick PM, MacDonald TT & Griffin GE. HIV infection of human intestinal explant cultures induces epithelial cell proliferation. AIDS, 1994; 8: 161–167. 12 Kelly P, Davies SE, Mandanda B et al. Enteropathy in Zambians with HIV related diarrhoea; regression modelling of potential determinants of mucosal damage. Gut, 1997; 41: 811–816. 13 Veitch AM, Kelly P, Zulu IS, Segal I & Farthing MJG. Tropical enteropathy: a T cell-mediated crypt hyperplastic enteropathy. Eur J Gastroenterol Hepatol, 2001; 13: 1175–1181. 14 Gathiram V & Jackson TF. A longitudinal study of asymptomatic carriers of pathogenic zymodemes of Entamoeba histolytica. S Afr Med J, 1987; 72: 669–672. 15 Gathiram V & Jackson TF. Frequency distribution of Entamoeba histolytica zymodemes in a rural South African population. Lancet, 1985; 1: 719–721. 16 Jackson TF, Sargeaunt PG, Williams JE & Simjee AE. Observations on zymodeme studies of Entamoeba histolytica in Durban, South Africa. Arch Invest Med (Mex), 1982; 13: 83–88. 17 Baveja UK, Francis S, Kaur M & Agarwal SK. The zymodemes of Entamoeba histolytica in New Delhi, India. J Diarrhoeal Dis Res, 1990; 8: 27–30. 18 Martinez-Garcia MC, Gutierrez-Trujillo G, Sanchez-Pares ME et al. Efficacy of zymodemes of E. histolytica technique in an epidemiologic study and report of new zymodemes in Mexico. Arch Invest Med (Mex), 1990; 21: 203–208. 19 WHO. The World Health Report 1998. Life in the 21st Century: A Vision for All. Geneva: World Health Organization; 1998. 20 Smith JH, Said MN & Kelada AS. Studies on schistosomal rectal and colonic polyposis. Am J Trop Med Hyg, 1977; 26: 80–84. 21 Chen et al. Colorectal cancer and schistosomiasis. Lancet, 1981; I: 971–973. 22 Warren KS, ed. Immunobiology and Molecular Biology of Parasitic Infections, 3rd edn. Oxford: Blackwell; 1993. 23 Cooper ES & Bundy DAP. In Diarrhoea and Malnutrition in Childhood, eds JA Walker-Smith & AS. McNeish London: Butterworth; 1986: 91. 24 Chanco PP & Vidad JY. A review of trichuriasis, its incidence, pathogenicity and treatment. Drugs, 1978; 15 (Suppl. 1): 87–93. 25 De Carneri I, Garofano M & Grass L. Investigation of the part played by Trichuris infections in delayed mental and physical development of children Northern Italy. Riv Parasitol, 1967; 28: 103–122. 26 Nime FA, Burek JS, Page DL, Holscher MA & Yardley JH. Acute entercolitis in a human being infected with the protozoan Cryptosporidium. Gastroenterology, 1976; 70: 592–598. 27 Meisel JL, Perera DR, Meligro C & Rubin CE. Overwhelming watery diarrhea associated with a Cryptosporidium in an immunosuppressed patient. Gastroenterology, 1976; 70: 1156–1160. 28 Adal KA, Sterling CR & Guerrant RL. In Infections of the Gastrointestinal Tract, eds MJ Blaser, PD Smith, JI Ravdin, HB Greenberg & RL Guerrant. New York: Raven Press Ltd; 1995: 1107–1128. 29 Roberts-Thomson IC & Mitchell GF. Giardiasis in mice. I. Prolonged infections in certain mouse strains and hypothymic (nude) mice. Gastroenterology, 1978; 75: 42–46. 30 Holberton DV. Attachment of Giardia – A hydrodynamic model based on flagellar activity. J Exp Biol, 1974; 60: 207–221. 31 Holberton DV. Fine structure of the ventral disc apparatus and the mechanism of attachment in the flagellate Giardia muris. J Cell Sci, 1973; 13: 11–41. 32 Feely DE, Schollmeyer JV & Erlandsen SL. Giardia spp. Distribution of contractile proteins in the attachment organelle. Exp Parasitol, 1982; 3: 145–154. 33 Crossley R & Holberton DV. Characterization of proteins from the cytoskeleton of Giardia lamblia. J Cell Sci, 1983; 59: 81–103. 34 Farthing MJG, Perreira MEA & Keusch GT. Description and characterisation of a surface lectin from Giardia lamblia. Infect Immun, 1986; 51: 661–667. 35 Lev B, Ward H, Keusch GT et al. Lectin activation in Giardia lamblia by host protease: a novel host–parasite interaction. Science, 1986; 232: 71–73. 36 Ward HD, Lev BI, Kane AV et al. Identification and characterization of Taglin, a mannose-6-phosphate binding, trypsin-activated lectin from Giardia lamblia. Biochemistry, 1987; 26: 8669–8675. 37 Teoh DA, Kamieniecki D, Pang G & Buret AG. Giardia lamblia rearranges F-actin and alpha-actinin in human colonic and duodenal monolayers and reduces transepithelial electrical resistance. J Parasitol, 2000; 86: 800–806. 38 Nash TE, Luján HT, Mowatt MR & Conrad JT. Variant-specific surface protein switching in Giardia lamblia. Infect Immun, 2001; 69: 1922–1923. 39 Aggarwal A & Nash TE. Antigenic variation of Giardia lamblia in vivo. Infect Immun, 1988; 56: 1420–1423. 40 Adam RD, Aggarwal A, Lal AA et al. Antigenic variation of a cysteine-rich protein in Giardia lamblia. J Exp Med, 1988; 167: 109–118. 41 Marcial MA & Madara JL. Cryptosporidium: cellular localization, structural analysis of absorptive cell–parasite interactions in guinea pigs, and suggestion of protozoan transport by M Cells. Gastroenterology, 1986; 90: 583–594. 42 Bird RG & Smith MD. Cryptosporidiosis enteritis in man: parasite life cycle and fine structural pathology. J Pathol, 1980; 132: 217–233. 43 Pollok RCG, McDonald V, Kelly MP & Farthing MJG. The role of Cryptosporidium parvum-derived phospholipase in intestinal epithelial cell invasion. Parasitol Res, 2003; 90: 181–186. 44 De Hovitz JA, Pape JW, Boncy M & Johnson WD. Clinical manifestations and therapy of Isospora belli infection in patients with AIDS. N Engl J Med, 1986; 315: 87–90. 45 Bendall RP, Lucas S, Moody A, Tovey G & Chiodini PL. Diarrhoea associated with cyanobacterium-like bodies: a new coccidian enteritis of man. Lancet, 1993; 341: 590–592. 46 Ortega YR, Sterling CR, Gilman RH, Cama VA & Diaz F. Cyclospora species – a new protozoan pathogen of humans. N Engl J Med, 1993; 328: 1308–1312. 47 Sun T, Hardi CF, Asnis D et al. Light and electron microscopic identification of Cyclospora species in the small intestine: Evidence of the presence of asexual life cycle in human host. Am J Clin Path, 1996; 105: 215–220. 48 Relman DA, Schmidt TM, Gajadhar A et al. Molecular phylogenetic analysis of Cyclospora, the human intestinal pathogen, suggests that it is closely related to Eimeria species. J Infect Dis, 1996; 173: 440–445. 49 Leippe M, Andra J, Nickel R, Tannich E & Muller-Eberhard HJ. Amoebapores, a family of membranolytic peptides from cytoplasmic granules of Entamoeba histolytica: isolation, primary structure, and pore formation in bacterial cytoplasmic membranes. Mol Microbiol, 1994; 14: 895–904. 50 Que X & Reed SL. Cysteine proteinases and the pathogenesis of amebiasis. Clin Microbiol Rev, 2000; 13: 196–206. 51 MacDonald TT & Spencer J. Evidence that activate mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine. J Exp Med, 1988; 167: 1341–1349. 52 Yardley JH, Takano J & Hendrix TR. Epithelial and other mucosal lesions of the jejunum in giardiasis. Jejunal biopsy studies. Bull Johns Hopkins Hosp, 1964; 115: 389–406. 53 Hartong WA, Gourley WK & Arvanitakis C. Giardiasis: Clinical spectrum and functional–structural abnormalities of the small intestinal mucosa. Gastroenterology, 1979; 77: 61–69. 54 Wright SG & Tomkins AM. Quantification of the lymphocytic infiltrate in jejunal epithelium in giardiasis. Clin Exp Immunol, 1977; 29: 408–412. 55 Gillon J. Clinical studies in adults presenting with giardiasis to a gastro-intestinal unit. Scott Med J, 1985; 30: 89–95. 56 Ferguson A, McClure JP & Townley RRW. Intraepithelial lymphocyte counts in small intestinal biopsies from children with diarrhoea. Acta Paediatr Scand, 1976; 65: 541–546. 57 Popovic O, Pendic B, Paljm A, Andrejevic M & Trpkovic D. Giardiasis, local immune defense and responses. Eur J Clin Invest, 1974; 4: 380. 58 Thompson A, Rowland R, Hecker R, Gibson GE & Reid DP. Immunoglobulin-bearing cells in giardiasis. J Clin Pathol, 1977; 30: 292–294. 59 Blenkinsopp WK, Gibson JA & Haffenden GP. Giardiasis and severe jejunal abnormality. Lancet, 1978; 1: 994. 60 Ridley MJ & Ridley DS. Serum antibodies and jejunal histology in giardiasis associated with malabsorption. J Clin Pathol, 1976; 29: 30–34. 61 Gillon J, Al Thamery D & Ferguson A. Features of small intestinal pathology (epithelial cell kinetics, intraepithelial lymphocytes, disaccharidases) in primary Giardia muris infection. Gut, 1982; 23: 498–506. 62 Ferguson A, Gillon J & Munro G. In Giardiasis, ed. EA. MeyerAmsterdam: Elsevier Science; 1990: 155–173. 63 Modigliani R, Bories C, Le Charpentier Y et al. Diarrhoea and malabsorption in AIDS: a study of four cases with special emphasis on opportunistic protozoan infections. Gut, 1985; 26: 179–187. 64 Goodgame RW, Kimball K, Ou CN et al. Intestinal function and injury in acquired immunodeficiency syndrome-related cryptosporidiosis. Gastroenterology, 1995; 108: 1075–1082. 65 Ravdin JI. Entamoeba histolytica: from adherence to enteropathy. J Infect Dis, 1989; 159: 420–429. 66 Reed SL, Keene WE & McKerrow JH. Thiol proteinase expression and pathogenicity of Entamoeba histolytica. J Clin Microbiol, 1989; 27: 2772–2777. 67 Muñoz ML, Lamoyi E, León G et al. Antigens in electron-dense granules from Entamoeba histolytica as possible markers for pathogenicity. J Clin Microbiol, 1990; 28: 2418–2424. 68 Schulte W & Scholze H. Action of the major protease from Entamoeba histolytica on proteins of the extracellular matrix. J Protozool, 1989; 36: 538–543. 69 Braga LL, Ninomiya H, McCoy JJ et al. Inhibition of the complement membrane attack complex by the galactose-specific adhesion of Entamoeba histolytica. J Clin Invest, 1992; 90: 1131–1137. 70 Beubler E, Kollar G, Saria A, Bukhave K & Rask-Madsen J. Involvement of 5-hydroxytryptamine, prostaglandin E2 and cyclic adenosine monophosphate in cholera toxin-induced fluid secretion in the small intestine of the rat in vivo. Gastroenterology, 1989; 96: 368–376. 71 Beubler E, Schuligoi R, Chopra AK, Ribardo & Peskar BA. Cholera toxin induces prostaglandin synthesis via post-transcriptional activation of cyclooxygenase-2 in the rat jejunum. J Path Exp Ther, 2002; 297: 940–945. 72 Argenzio RA, Leece J & Powell DW. Prostanoids inhibit intestinal NaCl absorption in experimental porcine cryptosporidiosis. Gastroenterology, 1993; 104: 440–447. 73 Eckmann L, Kagnoff MF & Fierer J. Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry. Infect Immun, 1993; 61: 4569–4574. 74 Yang S-K, Eckmann L, Panja A & Kagnoff MF. Differential and regulated expression of C-X-C, C-C and C chemokines by human colon epithelial cells. Gastroenterology, 1997; 113: 1214–1223. 75 Elliott EJ, Zhi Li, Bell C et al. A monoclonal antibody against the CD18 adhesion molecule inhibits colonic structural and ion transport abnormalities caused by Enterohaemorrhagic E. coli 0157:H7 in rabbits. Gastroenterology, 1994; 106: 1554–1561. 76 Laurent F, Eckmann L, Savidge TC et al. Cryptosporidium parvum infection of human intestinal epithelial cells induces the polarized secretion of C-X-C chemokines. Infect Immun, 1997; 65: 5067–5073. 77 Farthing MJG. The molecular pathogenesis of giardiasis. J Pediatr Gastroenterol Nutr., 1997; 24: 79–88. 78 Oberhuber G, Kastner N & Stolte M. Giardiasis. a histologic analysis of 567 cases. Scand J Gastroenterol, 1997; 32: 48–51. 79 Buret A, Hardin JA, Olsen ME & Gall DG. Pathophysiology of small intestinal malabsorption in gerbils infected with Giardia lamblia. Gastroenterology, 1992; 103: 506–513. 80 Wolfson JS, Richter JM, Waldron MA, Weber DJ, McCarthy DM & Hopkins CC. Cryptosporidiosis in immunocompetent patients. N Engl J Med, 1985; 312: 1278–1282. 81 Isaacs D, Hunt GH, Phillips AD, Price EH, Raafat F & Walker-Smith JA. Cryptosporidiosis in immunocompetent children. J Clin Pathol, 1985; 38: 76–81. 82 Haghighi P & Wolf PL. Tropical sprue and subclinical enteropathy. a vision for the nineties. Crit Rev Clin Lab Sci, 1997; 34: 313–341. 83 Farthing MJ. Diarrhoeal disease: current concepts and future challenges. Pathogenesis of giardiasis. Trans R Soc Trop Med Hyg, 1993; 87 (Suppl. 3): 7–21. 84 Oberhuber G, Vogelsang H, Stolte M, Muthenhaler S, Kummer AJ & Radaszkiewicz T. Evidence that intestinal intraepithelial lymphocytes are activated T cells in coeliac disease but not in giardiasis. Am J Pathol, 1996; 148: 1351–1357. 85 Maizels RM, Bundy DAP, Selkirk ME, Smith DF & Anderson RM. Immunological modulation and evasion by helminth parasites in human populations. Nature, 1993; 365: 797–805. 86 Romagnani S. Human Th1 and Th2 subsets: Regulation of differentiation and role in protection and immunopathology. Int Arch Allergy Appl Immunol, 1992; 98: 279–284. 87 Turner K, Fedde AL & Quinn EH. Non-specific potentiation of IgE by parasite infections in man. Int Arch Allergy Appl Immunol, 1979; 58: 232–238. 88 Urban JF, Madden KB, Svetic A et al. The importance of Th2 cytokines in protective immunity to nematodes. Immunol Rev, 1992; 127: 205–220. 89 Fraser EM, Christie JF & Kennedy MW. Heterogeneity amongst infected children in IgE antibody repertoire to the antigens of the parasitic nematode Ascaris. Int Arch Allergy Immunol, 1993; 100: 283–286. 90 Genta RM, Ottesen EA, Poindexter RW et al. Specific allergic sensitization to strongyloides antigens in human strongyloidiasis. Lab Invest, 1983; 48: 633–638. 91 McRury J, De Messias IT, Waltzer PD, Huitger T & Genta RM. Specific IgE response in human strongyloidiasis. Clin Exp Immunol, 1986; 65: 631–638. 92 Baird AW & O'Malley KE. Epithelial ion transport – possible contribution to parasite expulsion. Parasitol Today, 1993; 9: 141–143. 93 Harari Y, Russell DA & Castro GA. Anaphylaxis-mediated epithelial CI-secretion and parasite rejection in rat intestine. J Immunol, 1987; 138: 1250–1255. 94 Cooper ES, Spencer J, Whyte-Alleng CAM et al. Immediate hypersensitivity in colon of children with chronic Trichuris trichiura dysentery. Lancet, 1992; 338: 1104–1107. 95 Farthing MJG, Goka AKJ, Butcher PD & Arvind AS. Serodiagnosis of giardiasis. Serodiagn Immunother, 1987; 1: 233–238. 96 Goka AKJ, Rolston DDK, Mathan VI & Farthing MJG. Diagnosis of giardiasis by specific IgM antibody enzyme-linked immunosorbent assay. Lancet, 1986: ii: 184–186. 97 Goka AKJ, Rolston DDK, Mathan VI & Farthing MJG. Serum IgA response in human Giardia lamblia infection. Serodiagn Immunother, 1989; 3: 273–277. 98 Ament ME, Ochs HD & David SD. Structure and function of the gastrointestinal tract in primary immunodeficiency syndromes: a study in 39 patients. Medicine (Baltimore), 1973; 52: 227–248. 99 Webster ADB, Kenwright S, Ballard J et al. Nodular lymphoid hyperplasia of the bowel in primary hypogammaglobulinaemia. Gut, 1977; 18: 364–372. 100 Ament ME & Rubin CE. Relation of giardiasis to abnormal intestinal structure and function in gastrointestinal immunodeficiency syndromes. Gastroenterology, 1972; 62: 216–226. 101 Ward H, Jalan KN, Maitra TK, Aggarwal SK & Mahalanabis D. Small intestinal nodular lymphoid hyperplasia in patients with giardiasis and normal serum immunoglobulins. Gut, 1983; 24: 120–122. 102 Nagura H, Kohler PF & Brown WR. Immunocytochemical characterisation of lymphocytes in nodular lymphoid hyperplasia of the bowel. Lab Invest, 1979; 40: 66–73. 103 Snider DP & Underdown BJ. Quantitative and temporal analyses of murine antibody response in serum and gut secretions to infection with Giardia muris. Infect Immun, 1986; 52: 271–278. 104 Heyworth MF. Intestinal IgA responses to Giardia muris in mice depleted of helper T lymphocytes and in immunocompetent mice. J Parasitol, 1989; 75: 246–251. 105 Pape JW, Verdier RI, Boncy M & Johnston WD. Cyclospora infection in adults infected with HIV: clinical manifestations, treatment and prophylaxis. Ann Intern Med, 1994; 121: 654–657. 106 Lim SG, Condez CA, Lee CA, Johnson MA, Elia C & Poulter LW. Loss of mucosal CD4 lymphocytes is an early feature of HIV infection. Clin Exp Immunol, 1993; 92: 448–454. 107 Snijders F, Van Deventer SJH, Bartelsman JFW et al. Diarrhoea in HIV-infected patients: no evidence of cytokine-mediated inflammation in jejunal mucosa. AIDS, 1995; 9: 367–373. 108 Veitch AM, Kelly P, Zulu I, MacDonald TT & Farthing MJG. Lack of evidence for small intestinal mucosal T-cell activation as a pathogenic mechanism in African HIV-associated enteropathy. Dig Dis Sci, 2001; 46: 1133–1138. 109 Batman PA, Fleming SC, Sedgwick PM, MacDonald TT & Griffin GE. HIV infection of human fetal intestinal explant cultures induces intestinal epithelial cell proliferation. AIDS, 1994; 8: 161–167. 110 Zangole R, Riebnegger G, Wachter H & Fuchs D. Weight loss in HIV-1 infection is associated with immune activation. AIDS, 1993; 7: 175–181. Citing Literature Volume25, Issue5May 2003Pages 247-257 ReferencesRelatedInformation
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