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Recent developments with the L5178Y TK heterozygote mutagen assay system.

1973; National Institute of Environmental Health Sciences; Volume: 6; Linguagem: Inglês

10.1289/ehp.7306119

1552-9924

D. Clive,

Effects and risks of endocrine disrupting chemicals

Research ArticleOpen AccessRecent developments with the L5178Y TK heterozygote mutagen assay system. D Clive D Clive Search for more papers by this author Published:1 December 1973https://doi.org/10.1289/ehp.7306119Cited by:28AboutSectionsPDF ToolsDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InReddit FiguresReferencesRelatedDetailsCited by Finot F, Kaddour A, Morat L, Mouche I, Zaguia N, Cuceu C, Souverville D, Négrault S, Cariou O, Essahli A, Prigent N, Saul J, Paillard F, Heidingsfelder L, Lafouge P, Al Jawhari M, Hempel W, El May M, Colicchio B, Dieterlen A, Jeandidier E, Sabatier L, Clements J and M'Kacher R (2016) Genotoxic risk of ethyl-paraben could be related to telomere shortening, Journal of Applied Toxicology, 10.1002/jat.3425, 37:6, (758-771), Online publication date: 1-Jun-2017. Hsu C and Wang Q (2015) Genotoxicity Testing Strategies, Guidelines, and Methods Hamilton & Hardy's Industrial Toxicology, 10.1002/9781118834015.ch108, (1173-1188) Noda A, Hirai Y, Kodama Y, Kretzschmar W, Hamasaki K, Kusunoki Y, Mitani H, Cullings H and Nakamura N (2011) Easy detection of GFP-positive mutants following forward mutations at specific gene locus in cultured human cells, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 10.1016/j.mrgentox.2010.12.010, 721:1, (101-107), Online publication date: 1-Mar-2011. Toyokuni S, Sagripanti J and Hitchins V (1995) Cytotoxic and mutagenic effects of ferric nitrilotriacetate on L5178Y mouse lymphoma cells, Cancer Letters, 10.1016/0304-3835(94)03641-U, 88:2, (157-162), Online publication date: 1-Jan-1995. Liechty M, Rauchfuss H, Lugo M and Hozier J (1993) Sequence analysis of tka−-1 and tkb+-1 alleles in L5178Y tk+/− mouse-lymphoma cells and spontaneous tk−/− mutants, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(93)90195-L, 286:2, (299-307), Online publication date: 1-Apr-1993. Oglesby L, Brock K and Moore M (1989) Induced hepatocytes as a metabolic activation system for the mouse-lymphoma assay, Mutation Research/Genetic Toxicology, 10.1016/0165-1218(89)90122-5, 223:3, (295-302), Online publication date: 1-Jul-1989. de Serres F (1988) Heterozygous effects of multilocus deletions, Mutation Research/Reviews in Genetic Toxicology, 10.1016/0165-1110(88)90030-9, 196:1, (95-99), Online publication date: 1-Jul-1988. Moore M, Amtower A, Strauss G and Doerr C (1986) Genotoxicity of γ-irradiation in L5178Y mouse lymphoma cells, Mutation Research Letters, 10.1016/0165-7992(86)90107-7, 174:2, (149-154), Online publication date: 1-Jun-1986. Moore M, Clive D, Hozier J, Howard B, Batson A, Turner N and Sawyer J (1985) Analysis of trifluorothymidine-resistant (TFTr) mutants of L5178Y/TK+/− mouse lymphoma cells, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(85)90194-0, 151:1, (161-174), Online publication date: 1-Aug-1985. Krishna G, Xu J, Nath J, Petersen M and Ong T (1985) In vivo cytogenetic studies on mice exposed to ethylene dibromide, Mutation Research/Genetic Toxicology, 10.1016/0165-1218(85)90101-6, 158:1-2, (81-87), Online publication date: 1-Oct-1985. WOO Y, LAI D, ARCOS J and ARGUS M (1985) Structure–Activity Relationships Aliphatic and Polyhalogenated Carcinogens, 10.1016/B978-0-12-059323-1.50007-9, (3-414), . Moore M, Clive D, Howard B, Batson A and Turner N (1985) In situ analysis of trifluorothymidine-resistant (TFTr) mutants of L5178Y/TK+/− mouse lymphoma cells, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(85)90193-9, 151:1, (147-159), Online publication date: 1-Aug-1985. Jacobson E, Krell K, Olempska-Beer Z and Beer J (1984) UV-induced mutagenesis at the hypoxanthine—guanine phosphoribosyl transferase locus in two L5178Y mouse lymphoma cell strains with different UV sensitivities, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(84)90159-3, 129:2, (259-267), Online publication date: 1-Nov-1984. Nakamura N, Suzuki S, Ito A and Okada S (1982) Mutations induced by γ-rays and fast neutrons in cultured mammalian cells, Mutation Research Letters, 10.1016/0165-7992(82)90174-9, 104:6, (383-387), Online publication date: 1-Jul-1982. Djalali-Behzad G, Hussain S, Osterman-Golkar S and Segerbäck D (1981) Estimation of genetic risks of alkylating agents, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(81)90044-0, 84:1, (1-9), Online publication date: 1-Nov-1981. Moore-Brown M, Clive D, Howard B, Batson A and Johnson K (1981) The utilization of trifluorothymidine (TFT) to select for thymidine kinase-deficient (TK−/−) mutants from L5178Y/TK+/− mouse lymphoma cells, Mutation Research/Environmental Mutagenesis and Related Subjects, 10.1016/0165-1161(81)90227-2, 85:5, (363-378), Online publication date: 1-Oct-1981. Amacher D, Paillet S, Turner G, Ray V and Salsburg D (1980) Point mutations at the thymidine kinase locus in L5178Y mouse lymphoma cells II. Test validation and interpretation, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(80)90118-9, 72:3, (447-474), Online publication date: 1-Aug-1980. Amacher D and Paillet S (1980) Induction of trifluorothymidine-resistant mutants by metal ions in L5178Y/TK+/− cells, Mutation Research/Genetic Toxicology, 10.1016/0165-1218(80)90110-X, 78:3, (279-288), Online publication date: 1-Jul-1980. Rannug U (1980) Genotoxic effects of 1,2-dibromoethane and 1,2-dichloroethane, Mutation Research/Reviews in Genetic Toxicology, 10.1016/0165-1110(80)90020-2, 76:3, (269-295), Online publication date: 1-Nov-1980. Amacher D, Paillet S and Ray V (1979) Point mutations at the thymidine kinase locus in L5178Y mouse lymphoma cells, Mutation Research/Environmental Mutagenesis and Related Subjects, 10.1016/0165-1161(79)90109-2, 64:6, (391-406), Online publication date: 1-Dec-1979. Clive D, Johnson K, Spector J, Batson A and Brown M (1979) Validation and characterization of the L5178Y/TK+/- mouse lymphoma mutagen assay system, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(79)90195-7, 59:1, (61-108), Online publication date: 1-Jan-1979. Huang S and Lieberman M (1978) Induction of 6-thioguanine resistance in human cells treated with N-acetoxy-2-acetylaminofluorene, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(78)90285-3, 57:2, (349-358), Online publication date: 1-Jan-1978. Jacobson E, Krell K, Dempsey M, Lugo M, Ellingson O and William Hench C (1978) Toxicity and mutagenicity of radiation from fluorescent lamps and a sunlamp in L5178Y mouse lymphoma cells, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(78)90009-X, 51:1, (61-75), Online publication date: 1-Jul-1978. Abbondandolo A (1977) Prospects for evaluating genetic damage in mammalian cells in culture, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/S0027-5107(77)80030-4, 42, (279-297), Online publication date: 1-Jan-1977. Arlett C, Turnbull D, Harcourt S, Lehmann A and Colella C (1975) A comparison of the 8-azaguanine and ouabain-resistance systems for the selection of induced mutant Chinese hamster cells, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(75)90202-X, 33:2-3, (261-277), Online publication date: 1-Dec-1975. Anderson D and Fox M (1974) The induction of thymidine- and IUdR-resistant variants in P388 mouse lymphoma cells by x-rays, UV and mono- and bi- functional alkylating agents, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(74)90223-1, 25:1, (107-122), Online publication date: 1-Oct-1974. Clive D (1974) Mutagenicity of thioxanthenes (hycanthone, lucanthone and four indazole derivatives) at the TK locus in cultured mammalian cells, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/S0027-5107(74)80028-X, 26:4, (307-318), Online publication date: 1-Aug-1974. Rencüzoğulları E and Aydın M (2018) Genotoxic and mutagenic studies of teratogens in developing rat and mouse, Drug and Chemical Toxicology, 10.1080/01480545.2018.1465950, (1-21) Vol. 6December 1973Metrics About Article Metrics Publication History Originally published1 December 1973Published in print1 December 1973 Financial disclosuresPDF download License information EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted. Note to readers with disabilities EHP strives to ensure that all journal content is accessible to all readers. 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