Human serum immuno-reactive copper, zinc-superoxide dismutase assayed with an enzyme monoclonal immunosorbent in patients with digestive cancer
1989; Elsevier BV; Volume: 182; Issue: 2 Linguagem: Inglês
10.1016/0009-8981(89)90079-x
ISSN1873-3492
AutoresShinji Oka, Keiki Ogino, Shinjiro Matsuura, Syunji Yoshimura, Kazunari Yamamoto, Yukinori Okazaki, Tadayoshi Takemoto, Nobuyasu Kato, Taizo Uda,
Tópico(s)Vitamin C and Antioxidants Research
ResumoTwo types of monoclonal antibodies, N4 and N6, were raised against human copper, zinc-superoxide dismutase (Cu,Zn-SOD). An enzyme-linked immunosorbent assay for Cu,Zn-SOD was developed in sandwich method using these monoclonal antibodies. The measurable assay range was 1.0-100 micrograms/l and the coefficient of variation within and between series were 7.5% and 8.1%. Sera of 154 healthy control subjects displayed a low level (14 micrograms/l) of immunoreactive Cu,Zn-SOD with a logarithmic normal distribution. On the other hand, serum Cu,Zn-SOD levels were significantly elevated in patients with various digestive cancers.
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