Temporal progression of cortical reorganization following nerve injury
1990; Elsevier BV; Volume: 537; Issue: 1-2 Linguagem: Inglês
10.1016/0006-8993(90)90385-o
ISSN1872-6240
AutoresCatherine G. Cusick, John T. Wall, John H. Whiting, Ronald G. Wiley,
Tópico(s)Neural dynamics and brain function
ResumoDamage to peripheral nerves of adult mammals causes reorganization of somatosensory maps in the cerebral cortex. An understanding of the temporal progression of cortical changes is important for understanding the underlying mechanisms. The present expriments utilized neurophysiological recordings to analyze the time course of reorganization in the S-I cortical hindpaw area in adult rats. Following loss of sciatic inputs, the cortical area responding to low threshold inputs from the hindpaw saphenous nerve expands. A brief, early onset period of rapid expansion is followed by a prolonged period of slow increase. The temporal progression suggests that early onset changes condition the central nervous system for later changes.
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