CIRCADIAN VARIATION OF TACROLIMUS DISPOSITION IN LIVER ALLOGRAFT RECIPIENTS1
1996; Wolters Kluwer; Volume: 62; Issue: 8 Linguagem: Inglês
10.1097/00007890-199610270-00031
ISSN1534-6080
AutoresDavid I. Min, Hsiang‐Yin Chen, Alfredo J. Fabrega, Ferdinand O. Ukah, Youmin Wu, Claudia Corwin, Michael Ashton, Maureen Martin,
Tópico(s)Renal Transplantation Outcomes and Treatments
ResumoThe aim of this study was to characterize the circadian variation of oral tacrolimus disposition in 8 stable liver allograft recipients. In the steady state, a total of 23 blood samples was taken before and after tacrolimus administration during a 24-hr period and the pharmacokinetic parameters were compared. The area under the curve (AUC) of tacrolimus after the morning dose was significantly larger than after the evening dose (211+/-43 ng x hr/ml [morning] vs. 179+/-45 ng x hr/ml [evening], P=0.02). The time to peak (Tmax) was significantly shorter after the morning dose than after the evening dose (1.6+/-0.7 hr [morning] vs. 2.9+/-0.6 hr [evening], P=0.002). The peak (Cmax) was significantly higher after the morning dose than after the evening dose (32.2+/-10.2 ng/ml [morning] vs. 19.1+/-4.3 ng/ml [evening], P=0.003). However, the trough (Cmin) was not significantly different between the morning dose and the evening dose (13.1+/-3.9 ng/ml [morning] vs. 13.3+/-4.4 ng/ml [evening], P=0.4). This study demonstrated that tacrolimus disposition in liver transplant patients was determined by administration time.
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