Benzodioxane–benzamides as new bacterial cell division inhibitors
2014; Elsevier BV; Volume: 89; Linguagem: Inglês
10.1016/j.ejmech.2014.09.100
ISSN1768-3254
AutoresGiuseppe Chiodini, Marco Pallavicini, Carlo Zanotto, Massimiliano Bissa, Antonia Radaelli, Valentina Straniero, Cristiano Bolchi, Laura Fumagalli, Paola Ruggeri, Carlo De Giuli Morghen, Ermanno Valoti,
Tópico(s)Synthesis and Biological Evaluation
ResumoA SAR study was performed on 3-substituted 2,6-difluorobenzamides, known inhibitors of the essential bacterial cell division protein FtsZ, through a series of modifications first of 2,6-difluoro-3-nonyloxybenzamide and then of its 3-pyridothiazolylmethoxy analogue PC190723. The study led to the identification of chiral 2,6-difluorobenzamides bearing 1,4-benzodioxane-2-methyl residue at the 3-position as potent antistaphylococcal compounds.
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