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POLYCYSTIC OVARY SYNDROME: A CHANGING PERSPECTIVE

1989; Wiley; Volume: 31; Issue: 1 Linguagem: Inglês

10.1111/j.1365-2265.1989.tb00457.x

1365-2265

Stephen Franks,

Ovarian cancer diagnosis and treatment

Clinical EndocrinologyVolume 31, Issue 1 p. 87-120 POLYCYSTIC OVARY SYNDROME: A CHANGING PERSPECTIVE STEPHEN FRANKS, STEPHEN FRANKS Department of Obstetrics and Gynaecology, St Mary's Hospital Medical School, London W2 1PG, UKSearch for more papers by this author STEPHEN FRANKS, STEPHEN FRANKS Department of Obstetrics and Gynaecology, St Mary's Hospital Medical School, London W2 1PG, UKSearch for more papers by this author First published: July 1989 https://doi.org/10.1111/j.1365-2265.1989.tb00457.xCitations: 369AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References Abdulwahid, N.A., Adams, J., Van der Spuy, Z.M. & Jacobs, H.S. (1985) Gonadotrophin control of follicular development. Clinical Endocrinology, 23, 613– 626. Adams, J., Franks, S., Polson, D.W., Mason, H.D., Abdulwahid, N.A., Tucker, M., Morris, D.V., Price, J. & Jacobs, H.S. (1985) Multifollicular ovaries: clinical and endocrine features and response to pulsatile gonadotrophin releasing hormone. Lancet, ii, 1375– 1378. Adams, J., Polson, D.W. & Franks, S. (1986) Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism. British Medical Journal, 293, 355– 359. Adams, J., Tan, S.L., Wheeler, M.J., Morris, D.V., Jacobs, H.S. & Franks, S. (1988) Uterine growth in the follicular phase of spontaneous ovulatory cycles and during luteinizing hormone-releasing hormone-induced cycles in women with normal or polycystic ovaries. Fertility and Sterility, 49, 52– 55. Adashi, E.Y. & Resnick, C.E. (1986) Antagonistic interactions of transforming growth factors in the regulation of granulosa cell differentiation. Endocrinology, 119, 1879– 1881. Adashi, E.Y., Resnick, C.E., D'Ercole, A.J., Svoboda, M.E. & Van Wyk, J.J. (1985) Insulin-like growth factors as intra-ovarian regulators of granulosa cell growth and function. Endocrine Reviews, 6, 400– 420. Anderson, D.C. (1974) Sex hormone binding globulin. Clinical Endocrinology, 3, 69– 96. Aono, T., Miyazaki, M., Miyake, A., Kinugasa, T., Kurachi, K. & Matsumoto, K. (1977) Responses of serum gonadotrophins to LH-releasing hormone and oestrogens in Japanese women with polycystic ovaries. Acta Endocrinologica, 85, 840– 849. Arey, L.B. (1939) The degree of normal menstrual irregularity. American Journal of Obstetrics and Gynecology, 37, 12– 29. Bachmann, G.A. & Kemmann, E. (1982) Prevalence of oligomenorrhoea and amenorrhoea in a college population. American Journal of Obstetrics and Gynecology, 144, 98– 102. Baird, D.T., Abel, M.H., Kelly, R.W. & Smith, S.K. (1981) Endocrinology of dysfunctional uterine bleeding: the role of endometrial prostaglandins. In Endocrinology of Human Infertility: New Aspects (Eds P. G. Crosignani & B. L. Rubin), pp. 339– 417, Academic Press, London . Baird, D.T., Corker, C.S., Davidson, D.W., Hunter, W.M., Michie, E.A. & Van Look, P.F.A. (1977) Pituitary ovarian relationships in polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 45, 798– 809. Barbieri, R.L., Makris, A., Randall, R.W., Daniels, G., Kistner, R.W. & Ryan, K.J. (1986) Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism. Journal of Clinical Endocrinology and Metabolism, 62, 904– 909. Bardin, C.W. & Lipsett, M.B. (1967) Testosterone and androstenedione blood production rates in normal women and women with idiopathic hirsutism or polycystic ovaries. Journal of Clinical Investigation. 46, 891– 902. Barbieri, R.L., Makris, A., Randall, R.W., Daniels, G., Kistner, R.W. & Ryan, K.J. (1986) Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism. Journal of Clinical Endocrinology and Metabolism, 62, 904– 909. Bardin, C.W. & Lipsett, M.B. (1967) Testosterone and androstenedione blood production rates in normal women and women with idiopathic hirsutism or polycystic ovaries. Journal of Clinical Investigation, 46, 891– 902. Barnes, R.B., Rosenfield, R.L., Burstein, S. & Ehrmann, D.A. (1989) Pituitary-ovarian responses to naferelin testing in polycystic ovary syndrome. New England Journal of Medicine, 320, 559– 565. Brook, C.G.D., Jacobs, H.S. & Stanhope, R. (1988) Polycystic ovaries in childhood. (Editorial) British Medical Journal, 296, 878. Buckler, H.M., McLachlan, R.I., Maclachlan, V.B., Healy, D.L. & Burger, H.G. (1988) Serum inhibin levels in polycystic ovary syndrome: basal levels and response to luteinizing hormone-releasing hormone agonist and exogenous gonadotrophin administration. Journal of Clinical Endocrinology and Metabolism, 66, 798– 803. Burger, C.W., Korsen, T., Van Kessel, H., Van Dop, P.A., Caron, F.J.M. & Schoemaker, J. (1985) Pulsatile luteinizing hormone patterns in the follicular phase of the menstrual cycle, polycystic ovarian disease (PCOD) and non PCOD secondary amenorrhoea. Journal of Clinical Endocrinology and Metabolism, 61, 1126– 1132. Burghen, G.A., Givens, J.R. & Kitabchi, A.E. (1980) Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease. Journal of Clinical Endocrinology and Metabolism, 50, 113– 116. Buvat, J., Siane-Mowett, C., Fourlinne, J.C., Lenaire, A., Buvat-Herbaut, M. & Hernard, E. (1982) Androgens and prolactin levels in hirsute women with either polycystic ovaries or 'borderline ovaries'. Fertility and Sterility, 38, 695– 700. Chang, R.J., Laufer, L.R., Meldrum, D.R., Defazio, J., Lu, J.K.H., Vale, W.W., Rivier, J.E. & Judd, H. (1983a) Steroid secretion in polycystic ovarian disease after ovarian suppression by a long-acting gonadotropin-releasing agonist. Journal of Clinical Endocrinology and Metabolism, 56, 897– 903. Chang, R.J., Nakamura, R.M., Judd, H.L. & Kaplan, S.A. (1983b) Insulin resistance in non-obese patients with polycystic ovarian disease. Journal of Clinical Endocrinology and Metabolism, 57, 356– 359. Chiazze, L., Brayer, F.T., Macisco, J.J., Parker, M.P. & Duffy, B.J. (1968) The length and variability of the human menstrual cycle. Journal of rhe American Medical Association, 203, 377– 380. Corenblum, B. & Taylor, P.J. (1982) The hyperprolactinemic polycystic ovary syndrome may not be a distinct entity. Fertility and Sterility, 38, 549– 552. Couzinet, B., Lestrat, N., Brailly, S. & Schaison, G. (1986) Comparative effects of cyproterone acetate or a long acting gonadotrophin-releasing-hormone agonist in polycystic ovarian disease. Journal of Clinical Endocrinology and Metabolism, 63, 1031– 1035. Dewis, P., Newman, M., Ratcliffe, W.A. & Anderson, D.C. (1986) Does testosterone affect the normal menstrual cycle. Clinical Endocrinology, 24, 515– 521. Dunaif, A., Graf, M., Mandeli, J., Laumas, V. & Dobrjansky, A. (1987) Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance and/or hyperinsulinemia. Journal of Clinical Endocrinology and Metabolism, 65, 499– 507. Dunaif, A., Mandeli, J., Fluhr, H. & Dobrjansky, A. (1988) The impact of obesity and chronic hyperinsulinemia on gonadotropin release and gonadal steroid secretion in the polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 66, 131– 139. Edman, C.D. & MacDonald, P.C. (1978) Effect of obesity on conversion of plasma androstenedione to estrone in ovulatory and anovulatory young women. American Journal of Obstetrics and Gynecology, 130, 456– 463. Erickson, G.F., Magoffin, D.A., Dyer, C.A. & Hofeditz, C. (1985) The ovarian androgen producing cells: a review of structure/function relationships. Endocrine Reviews, 6, 371– 399. Eshel, A., Abdulwahid, N.A., Armar, N.A., Adams, J. & Jacobs, H.S. (1988) Pulsatile luteinising hormone releasing hormone therapy in women with polycystic ovary syndrome. Fertility and Sterility 49, 956– 960. Falaschi, P., Del Pozo, E., Rocco, A., Toscano, V., Btrangeu, E., Pompei, P. & Frajese, G. (1980) Prolactin release in polycystic ovary. Obstetrics and Gynaecology. 55, 579– 582. Finklestein, M. & Weidenfeld, J. (1983) Perceptions on the etiology of the polycystic ovary syndrome. In Hormones in Normal and Abnormal Tissues, pp. 45– 62. Walter Gruyter, Berlin , New York . Franks, S. (1987) Primary and secondary amenorrhoea. British Medical Journal, 294, 815– 819. Franks, S., Adams, J., Mason, H. & Polson D. (1985) Ovulatory disorders in women with polycystic ovary syndrome. Clinics in Obstetrics and Gynaecology, 12, 605– 632. Franks, S., Mason, H.D., Polson, D.W., Winston, R.M.L., Margara, R. & Reed, M.J. (1988) Mechanism and management of ovulatory failure in women with polycystic ovary syndrome. Human Reproduction, 3, 531– 534. Franks, S., Polson, D.W. & Reed, M.J. (1989) Physiopathology and diagnosis of polycystic ovary syndrome: the significance of 11 β-hydroxyandrostenedione. In Advances in Gynaecological Endocrinology. Volume 1 (Ed. A. R. Genazzani), pp. 289– 294. Parthenon , Carnforth , Lancs (in press). Franks, S., Nabarro, J.D.N. & Jacobs, H.S. (1977) Prevalence and presentation of hyperprolactinaemia in patients with 'functionless' pituitary tumours. Lancet, 1, 778– 780. Futterweit, W. (1983) Pituitary tumours and polycystic ovarian disease. Obstetrics and Gynecology, 62, S74– S79. Futterweit, W. (1984) Pathologic anatomy of polycystic ovarian disease. In Polycystic Ovarian Disease (Ed. W. Futterweit), pp. 41– 46, Springer-Verlag, New York . Futterweit, W. & Krieger, D.T. (1979) Pituitary tumours associated with hyperprolactinaemia and polycystic ovarian disease. Fertility and Sterility, 31, 608– 613. Gambrell, Jr, R.D., Greenblatt, R.B. & Mahesh, V.B. (1973) Inappropriate secretion of LH in the Stein-Leventhal syndrome. Obstetrics and Gynecology, 42, 429– 440. Garcea, N., Campo, S., Paretta, V., Venneri, M., Siccardi, P., Darnegio, R. & de Tomasi, F. (1985) Induction of ovulation with purified urinary follicle-stimulating hormone in patients with polycystic ovarian syndrome American Journal of Obstetrics and Gynecology, 151, 635– 640. Garcia, J.E., Jones, G.S. & Wentz, A.C. (1977) The use of clomiphene citrate. Fertility and Sterility, 28, 707– 717. Givens, J.R. (1976) Hirsutism and hyperandrogenism. Advances in Internal Medicine, 21, 221– 247. Givens, J.R. (1977) Polycystic ovarian disease. In Gynecologic Endocrinology (Ed. J.R. Givens), pp. 127– 142, Year Book Medical Publishers, Chicago . Givens, J.R. (1984) Polycystic ovaries-a sign not a diagnosis. In Polycystic Ovary Disease. Seminars in Reproductive Endocrinology (Ed. R.J. Chang), 2, pp. 271– 280, Springer-Verlag, New York . Givens, J.R., Andersen, R.N., Umstot, E.S. & Wiser, W.L. (1976) Clinical findings and hormonal response in patients with polycystic ovarian disease with normal versus elevated LH levels. Obstetrics and Gynecology, 47, 388– 394. Goldzieher, J.W. & Axelrod, L.R. (1963) Clinical and biochemical features of polycystic ovarian disease. Fertility and Sterility, 14, 631– 653. Goldzieher, J.W. & Green, J.A. (1962) The polycystic ovary. I Clinical and histological features. Journal of Clinical Endocrinology and Metabolism, 22, 325– 338. Goldzieher, J.W., Pena, A. & Aivaliotis, M.M. (1978) RIA of androstenedione, testosterone and 11-hydroxyandrostenedione after chromatography on Lipidex 5000. Journal of Steroid Biochemistry, 9, 169– 175. Green, J.A. & Goldzieher, J.W. (1965) The polycystic ovary. Light and electron microscope studies. American Journal of Obstetrics and Gynecology, 91, 173– 181. Hague, W.M., Adams, J., Rodda, C., Brook, C.G.D., Dewhurst, C.J. & Jacobs, H.S. (1986a) Prevalence of ultrasonically detected polycystic ovaries in females with congenital adrenal hyperplasia. Journal of Endocrinology, 111 (Suppl.), Abstract 46. Hague, W., Adam, J., Reeders, S., Peto, T.E.A. & Jacobs, H.S. (1988) Familial polycystic ovaries: a genetic disease. Clinical Endocrinology, 29, 593– 606. Harlass, F.E., Plymate, S.R., Fariss, B.L. & Belts, R.P. (1984) Weight loss is associated with correction of gonadotrophin and sex steroid abnormalities in the obese anovulatory female. Fertility and Sterility, 42, 649– 651. Harlow, C.R., Shaw, H.J., Hillier, S.G. & Hodges, J.K. (1988) Factors influencing follicle-stimulating hormone-responsive steroidogenesis in marmoset granulosa cells: effects of androgens and the stage of follicular maturity. Endocrinology, 122, 2780– 2787. Hillier, S.G. (1981) Regulation of follicular oestrogen biosynthesis: a survey of current concepts. Journal of Endocrinology, 89, 3P– 18P. Hillier, S.G. (1985) Sex steroid metabolism and follicular development in the ovary. In Oxford Reviews of Reproductive Biology. Vol 7 (Ed. J. R. Clarke), pp. 168– 222. Clarendon Press, Oxford . Homburg, R., Weissglas, L. & Goldman, J. (1988) Improved treatment for anovulation in polycystic ovarian disease utilizing the effect of progesterone on the inappropriate gonadotrophin release and clomiphene response. Human Reproduction, 3, 285– 288. Horton, R., Lobo, R. & Hawkes, D. (1982) Androstanediol glucuronide in plasma: a marker of androgen action. Journal of Clinical Investigation, 69, 1203– 1206. Hsueh, A.J.W., Welsh, T.H. & Jones, P.B.C. (1981) Inhibition of ovarian and testicular steroidogenesis by epidermal growth factor. Endocrinology, 108, 2002– 2004. Jacobs, H.S., Franks, S., Murray, M.A.F., Hull, M.G.R., Steele, S.J. & Nabarro, J.D.N. (1976) Clinical and endocrine features of hyperprolactinaemic amenorrhoea. Clinical Endocrinology, 5, 439– 454. Jaffe, R.M. & Kaye, W.R. (1974) Estradiol augmentation of pituitary responsiveness to gonadotrophin-releasing hormone in women. Journal of Clinical Endocrinology and Metabolism, 39, 850– 855. Jeffcoate, T.N.A. (1963) The androgenic ovary, with special reference to the Stein-Leventhal syndrome. American Journal of Obstetrics and Gynecology, 88, 143– 156. Jia, X.C. & Hsueh, A.J.W. (1986) Granulosa cell aromatase bioassay for follicle-stimulating hormone: validation and application of the method. Endocrinology, 119, 1570– 1577. Kamrava, M.M., Seibel, M.M., Berger, M.J., Thompson, I. & Taymor, M.L. (1982) Reversal of persistent anovulation in polycystic ovarian disease by administration of chronic low-dose follicle-stimulating hormone. Fertility and Sterility, 37, 520– 523. Kandeel, F.R., Butt, W.R., London, D.R., Lynch, S.S., Edwards, R.L. & Rudd, B.T. (1978) Oestrogen amplification of LH-RH response in the polycystic ovary syndrome and response to clomiphene. Clinical Endocrinology, 9, 429– 441. Kazer, R.R., Kessell, B. & Yen, S.S.C. (1987) Circulating luteinizing hormone pulse frequency in women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 65, 233– 236. Kiddy, D., Reed, M.J., Scanlon, M.J., Mason, H.D., Bray, C., Polson, D.W., Sagle, M. & Franks, S. (1988) The effect of obesity on clinical and endocrine presentation in women with polycystic ovary syndrome (PCOS). Journal of Endocrinology, 117 (Suppl.), Abstract 220. Kirschner, M.A. & Bardin, C.W. (1972) Androgen production and metabolism in normal and virilized women. Metabolism, 21, 667– 688. Kirschner, M.A., Samojlik, E. & Silber, D. (1983) A comparison of androgen production and clearance in hirsute and obese women. Journal of Steroid Biochemistry, 19, 607– 614. Kirschner, M.A., Zucker, I.R. & Jespersen, D. (1976) Idiopathic hirsutism-an ovarian abnormality. New England Journal of Medicine, 294, 637– 640. Knobil, E. (1980) The neuroendocrine control of the menstrual cycle. Recent Progress in Hormone Research, 36, 53– 88. Kopelman, P.G., Pilkington, T.R.E., White, N. & Jeffcoate, S.L. (1981) The effect of weight loss on sex steroid secretion and binding in massively obese women. Clinical Endocrinology, 14, 113– 116. Krouse, T.B. (1988) Menopausal pathology. In The Menopause: Conservative Management. Second edition. (Ed. B.A. Eskin), pp. 29– 79, Macmillan, New York . Kudlow, J.E., Kobrin, M.S., Purchio, A.F., Twardzik, D.R., Hernandez, E.R., Asa, S.L. & Adashi, E.Y. (1987) Ovarian transforming growth factor-α gene expression: immunohistochemical localization to the theca-interstitial cells. Endocrinology, 121, 1577– 1579. Kurtz, B.R., Givens, J.R., Komindr, S., Stevens, M.D., Karas, J.G., Bittle, J.B., Judge, D. & Kitabchi, A.E. (1987) Maintenance of normal circulating levels of delta-4-androstenedione and dehydroepiandros-terone in simple obesity despite increased metabolic clearance rates: evidence for a servo-control mechanism. Journal of Clinical Endocrinology and Metabolism, 64, 1261– 1267. Lobo, R.A. (1985) Disturbances of androgen secretion and metabolism in polycystic ovary syndrome. Clinics in Obstetrics and Gynaecology, 12, 633– 647. Lobo, R.A., Granger, L., Goebelsmann, U. & Mishell, J.R. (1981) Elevations in unbound serum estradiol as a possible mechanism for inappropriate gonadotrophin secretion in women with PCO. Journal of Clinical Endocrinology and Metabolism, 52, 156– 158. Luciano, A.A., Chapler, F.K. & Sherman, B.M. (1984) Hyperprolactinaemia in polycystic ovary syndrome. Fertility and Sterility, 41, 719– 725. MacGregor, A.H., Johnson, J.E. & Bunde, C.A. (1968) Further clinical experience with clomiphene citrate. Fertility and Sterility, 19, 616– 620. Martin, W.H., Rogol, A.D., Kaiser, D.L. & Thorner, M.O. (1981) Dopaminergic mechanisms and luteinizing hormone (LH) secretion. II Differential effects of dopamine and bromocriptine on LH release in normal women. Journal of Clinical Endocrinology and Metabolism, 52, 650– 656. Maschler, I., Salzberger, M. & Finklestein, M. (1975) 11-hydroxylase with affinity to C-21-deoxysteroids from ovaries of patients with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 41, 999– 1008. Mason, H.D., Sagle, M., Polson, D.W., Kiddy, D., Dobriansky, D., Adams, J. & Franks, S. (1988) Reduced frequency of luteinizing hormone pulses in women with weight loss-related amenorrhoea and multifollicular ovaries. Clinical Endocrinology, 28, 611– 618. McArthur, J.W., Ingersoll, F.M. & Worcester, J. (1958) The urinary excretion of interstitial-cell and follicle-stimulating hormone activity by women with diseases of the reproductive system. Journal of Clinical Endocrinology and Metabolism, 18, 1202– 1215. McKenna, T.J. (1988) Pathogenesis and treatment of polycystic ovary syndrome. The New England Journal of Medicine, 318, 558– 562. McLachlan, R.I., Robertson, D.M., De Kretser, D.M. & Burger, H.G. (1988) Advances in the physiology of inhibin and inhibin-related peptides. Clinical Endocrinology, 29, 77– 114. Miller, W.L. (1988) Molecular biology of steroid hormone synthesis. Endocrine Reviews, 9, 295– 318. Molloy, B.G., el Scheikh, M.A.A., Chapman, C., Oakey, R.E., Hancock, K.W. & Glass, M.R. (1984) Pathological mechanisms in polycystic ovary syndrome: modulation of LH pulsatility by progesterone. British Journal of Obstetrics and Gynaecology, 91, 457– 465. Murdoch, A.P., Dunlop, W., Kendall-Taylor, P. & Watson, M. (1984) The acute effects of dopamine antagonist on luteinizing hormone, follicle-stimulating hormone, prolactin and thyroid-stimulating hormone secretion in polycystic ovarian syndrome: differential effect of ovulation. Clinical Endocrinology, 21, 611– 619. Murdoch, A.P., McClean, K.G., Watson, M.J., Dunlop, W. & Kendall-Taylor, P. (1987) Treatment of hirsutism in polycystic ovary syndrome with bromocriptine. Brirish Journal of Obstetrics and Gynaecology, 94, 358– 365. Nabarro, J.D.N. (1982) Pituitary prolactinomas. Clinical Endocrinology, 17, 129– 155. Pardridge, W.M. (1986) Serum bioavailability of sex steroid hormones. Clinics in Endocrinology and Metabolism, 15, 259– 278. Paris, L., Tramonti, M., Casciano, S., Zurli, A. & Gazzarrini, O. (1982) The role of ultrasound in the study of polycystic ovarian disease. Journal of Clinical Ultrasound, 10, 167– 172. Pasquali, R., Casimirri, F., Venturoli, S., Paradis, R., Mattioli, L., Capelli, M., Meichionda, N. & Lam, G. (1983) Insulin resistance in patients with polycystic ovaries: its relationship to body weight and androgen levels. Acta Endocrinologica (Copenh). 104, 110– 116. Plymate, S.R., Fariss, B.L., Bassett, M.L. & Matej, L. (1981) Obesity and its role in polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 52, 1246– 1248. Plymate, S.R., Matej, L.A., Jones, R.E. & Friedl, K.E. (1988) Inhibition of sex hormone-binding globulin production in human hepatoma (Hep G2) cell line by insulin and prolactin. Journal of Clinical Endocrinology and Metabolism, 67, 460– 464. Polson, D.W., Adams, J., Steer, P.J. & Franks, S. (1986) Unilateral polycystic ovary. Case report. British Journal of Obstetrics and Gynaecology, 93, 1100– 1103. Polson, D.W., Adams, J., Wadsworth, J. & Franks, S. (1988a) Polycystic ovaries-a common finding in normal women. Lancet, i, 870– 872. Polson, D.W., Franks, S., Reed, M.J., Cheng, R.W., Adams, J. & James, V.H.T. (1987c) The distribution of oestradiol in plasma in relation to uterine cross-sectional area in women with polycystic or multifollicular ovaries. Clinical Endocrinology, 26, 581– 588. Polson, D.W., Kiddy, D.S., Mason, H.D. & Franks, S. (1989) Induction of ovulation with clomiphene citrate in women with polycystic ovary syndrome: the difference between responders and non-responders. Fertility and Sterility, 51, 30– 34. Polson, D.W., Mason, H.D. & Franks, S. (1987a) Bromocriptine treatment of women with clomiphene-resistant polycystic ovary syndrome. Clinical Endocrinology, 26, 197– 203. Polson, D.W., Mason, H.D., Saldahna, M.B.Y. & Franks, S. (1987b) Ovulation of a single dominant follicle during treatment with low-dose pulsatile follicle stimulating hormone in women with polycystic ovary syndrome. Clinical Endocrinology, 26, 205– 212. Polson, D.W., Reed, M.J., Franks, S., Scanlon, M.J. & James, V.H.T. (1988b) Serum 11-hydroxyandrostene-dione as an indicator of the source of excess androgen production in women with polycystic ovaries. Journal of Clinical Endocrinology and Metabolism. 66, 946– 950. Polson, D.W., Reed, M.J., Scanlon, M.J., Quiney, N. & Franks, S. (1988c) Androstenedione concentrations following dexamethasone suppression: correlation with clomiphene responsiveness in women with polycystic ovary syndrome. Gynecological Endocrinology, 2, 257– 264. Poretsky, L. & Kalin, M.F. (1987) The gonadotrophic function of insulin. Endocrine Reviews, 8, 132– 145. Quigley, M.E., Rakoff, J.S. & Yen, S.S.C. (1981) Increased luteinizing hormone sensitivity to dopamine inhibition in polycystic ovary syndrome. Journal of Clinical Endocrinology and Meraboli.sm, 52, 231– 234. Rebar, R., Judd, H.L., Yen, S.S.C., Rakoff, J., Vandenberg, G. & Naftolin, F. (1976) Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome. Journal of Clinical Investigation. 57, 1320– 1329. Reed, M.J. & Franks, S. (1988) Anti-androgens in gynaecological practice. Clinical Obstetrics and Gynaecology, 2, 581– 595. Remouchamps, L. & Ghijsbrecht, P.F. (1953) Contribution a l'etude endocrinologique des facteurs de virilization chez la femme. Acra Clinica Belgica, 8, 348– 362. Sagle, M., Kiddy, D., Mason, H.D., Dobriansky, D., Polson, D.W. & Franks, S. (1988) Evidence for normal hypothalamic regulation of LH in ovulatory women with polycystic ovaries (PCO). In Proceedings of VII Renier de Graaf Symposium (Ed. R. Rolland), Elsevier, Amsterdam . Scanlon, M.J., Whorwood, C.B., Franks, S., Reed, M.J. & James, V.H.T. (1988) Serum androstanediol glucuronide concentrations in normal and hirsute women and patients with thyroid dysfunction. Clinical Endocrinology, 29, 529– 538. Scanlon, M.J., Whorwood, C.B., Reed, M.J., Franks, S. & James, V.H.T. (1987) Androsterone glucuronide: a marker of peripheral androgen metabolism. Journal of Endocrinology. 115 (Suppl.), Abstract 131. Schlechte, J., Sherman, B. & Halmi, N. (1980) Prolactin-secreting pituitary tumours in amenorrheic women: a comprehensive study. Endocrine Reviews. 1, 295– 308. Shaw, R.W., Duigan, N.M., Butt, W.R., Logan-Edwards, R. & London, R. (1975) Hypothalamic-pituitary relationships in the polycystic ovary syndrome: serum gonadotrophin levels following injection of oestradiol benzoate. Brirish Journal of Obstetrics and Gynaecology. 82, 952– 957. Siebel, M.M., Oskowitz, S., Kamrava, M. & Taymor, M.L. (1984) Bromocriptine response in normoprolactinaemic patients with polycystic ovary disease: a preliminary report. Obstetrics and Gynaecology, 64, 213– 218. Siiteri, P.K. & MacDonald, P.C. (1973) Role of extraglandular estrogen in human endocrinology. In Handhook of Physiology: Endocrinology (Eds R. O. Greep & E. B. Astwood), II(7). pp. 615– 629, American Physiological Society, Washington . DC . Siiteri, P.K. & Simberg, N.H. (1986) Changing concepts of active androgens in blood. Clinics in Endocrinology and Metabolism. 15, 247– 258. Smith, K.D., Steinberger, E. & Perloff, W.H. (1965) Polycystic ovarian disease. A report of 301 patients. American Journal of Obstetrics and Gynecology, 93, 994– 1001. Spruce, B.A., Kendall-Taylor, P., Dunlop, W., Anderson, A.J., Watson, M.J., Cook, D.B. & Gray, C. (1984) The effect of bromocriptine in the polycystic ovary syndrome. Clinical Endocrinology, 20, 481– 488. Stanhope, R., Adams, J., Pringle, J.P., Jacobs, H.S. & Brook, C.G.D. (1987) The evolution of polycystic ovaries in a girl with hypogonadotrophic hypogonadism before puberty and during puberty induced with pulsatile gonadotrophin-releasing hormone. Fertility and Sterility, 47, 872– 875. Stein, I.F. & Leventhal, M.L. (1935) Amenorrhoea associated with bilateral polycystic ovaries. American Journal of Obstetrics and Gynecology, 29, 181– 191. Swanson, M., Sauerbrei, E.E. & Cooperberg, P.L. (1981) Medical implications of ultrasonically detected polycystic ovaries. Journal of Clinical Ultrasound, 9, 219– 222. Thorner, M.O., McNeilly, AS., Hagan, C. & Besser, G.M. (1974) Long term treatment of galactorrhoea and hypogonadism with bromocriptine. British Medical Journal, 2, 419– 422. Vejlsted, H. & Albrechtsen, R. (1976) Biochemical and clinical effect of ovarian wedge resection in the polycystic ovary syndrome. Obstetrics and Gynecology, 47, 575– 580. Venturoli, S., Porcu, E., Fabbri, R., Magrini, O., Gammi, L., Paradisi, R., Forcacci, M., Bolzani, R. & Flamigni, C. (1988) Episodic pulsatile secretion of FSH, LH, prolactin, oestradiol, oestrone. and LH circadian variations in polycystic ovary syndrome. Clinical Endocrinology, 28, 93– 107. Waldstreicher, J., Santoro, N.F., Hall, J.E., Filicori, M. & Crowley Jr, W.F. (1988) Hyperfunction of the hypothalamic pituitary axis in women with polycystic ovarian disease: indirect evidence for partial gonadotrope desensitization. Journal of Clinical Endocrinology and Metabolism, 66, 165– 172. Wood, C., Larsen, L. & Williams, R. (1979) Menstrual characteristics of 2,343 women attending the Shepherd Foundation. Australian and New Zealand Journal of Obstetrics and Gynaecology, 19, 107– 110. Yen, S.S.C. (1978) Chronic anovulation due to inappropriate feedback system. In Reproductive Endocrinology (Eds S. S. C. Yen & R. Jaffe), pp. 297– 323, W.B. Saunders, Philadelphia . Yen, S.S.C. (1980) The polycystic ovary syndrome. Clinical Endocrinology, 12, 177– 207. Yen, S.S.C., Vela, P. & Rankin, J. (1970) Inappropriate secretion of folhcle-stimulating hormone and luteinizing hormone in polycystic ovarian disease. Journal of Clinical Endocrinology and Metabolism, 30, 435– 442. Yen, S.S.C., Vandenberg, G., Rebar, R. & Ehara, Y. (1972) Variation of pituitary responsiveness to synthetic LRF during different phases of the menstrual cycle. Journal of Clinical Endocrinology and Metabolism, 25, 931– 934. Zumoff, B., Freeman, R., Coupey, S., Saenger, P., Markowitz, M. & Kream, J. (1983) A chronobiologic abnormality in luteinizing hormone secretion in teenage girls with the polycystic ovary syndrome. The New England Journal of Medicine, 309, 1206– 1209. Citing Literature Volume31, Issue1July 1989Pages 87-120 ReferencesRelatedInformation