Monoclonal anti‐biotin antibodies simulate avidin m the recognition of biotin
1993; Wiley; Volume: 322; Issue: 1 Linguagem: Inglês
10.1016/0014-5793(93)81108-c
ISSN1873-3468
AutoresHasan Bağcı, Förtüne Kohen, Unsal Kusçuoglu, Edward A. Bayer, Meir Wilchek,
Tópico(s)Cellular transport and secretion
ResumoThe sequence of the V H gene of a monoclonal anti‐biotin antibody was determined. Biotin‐binding motifs, similar to those in avidin and streptavidin, were identified in complementarity determining regions 2 and 3, suggesting that natural selection of functional motifs may occur in unrelated protein types.
Referência(s)