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Antiulcerogenic Activity of Some Sesquiterpene Lactones Isolated from Artemisia annua

2002; Thieme Medical Publishers (Germany); Volume: 68; Issue: 6 Linguagem: Inglês

10.1055/s-2002-32570

1439-0221

Mary Ann Foglio, Patrı́cia Corrêa Dias, Márcia Aparecida Antônio, Ana Possenti, Rodney Alexandre Ferreira Rodrigues, Érica Ferreira da Silva, Vera Lúcia Garcia Rehder, João Ernesto de Carvalho,

Botanical Research and Chemistry

Artemisinin 1, dihydro-epideoxyarteannuin B 2 and deoxyartemisinin 3 were isolated from the sequiterpene lactone-enriched fraction obtained from the crude ethanolic extract of Artemisia annua L. These compounds were tested on ethanol and indomethacin-induced ulcer models. Compound 1 did not afford cytoprotection under the experimental models tested. Only compounds 2 and 3 decreased the ulcerative lesion index produced by ethanol and indomethacin in rats. These compounds did not demonstrate antiulcerogenic activity when tested on the ethanol-induced ulcer model, with previous administration of indomethacin, suggesting that the antiulcerogenic activity is a consequence of prostaglandin synthesis increase.