The physiological effects of hypoxia on the erythrocytes of the chick embryo
1970; Elsevier BV; Volume: 23; Issue: 2 Linguagem: Inglês
10.1016/0012-1606(70)90101-6
ISSN1095-564X
Autores Tópico(s)Pregnancy and preeclampsia studies
ResumoChick embryos ranging in age from 6 to 18 days were exposed to a low oxygen (13%) environment for 1 day. Embryos were analyzed on each odd day of incubation between day 7 and day 19 for changes within the blood picture. Tests included determinations of the number of erythrocytes, the erythrocyte volume, the hemoglobin concentration, the erythrocyte stages, and embryonic weights and stages. Following a low oxygen incubation embryos of greater than 12 days of age demonstrated an enhancement of both the erythrocyte and hemoglobin concentrations. This response was heightened as the embryo aged. The mean erythrocyte volume was significantly larger in the 7-, 11-, 15-, and 17-day embryos exposed to 13% oxygen as compared with their controls. Changes in erythrocyte stage were also noted in oxygen-deficient embryos. In general the most mature RBC stages present at any time comprised a greater proportion of the total population in control animals as compared with the stressed. Embryonic weight and stage were minimally affected by the hypoxic environment. The rise in erythrocyte and hemoglobin levels in older animals following a 1-day exposure to 13% oxygen was thought to be caused by the activation of certain homeostatic mechanisms developing during the second half of incubation. The differentiation of the metanephric kidney was considered an important event in the establishment of these mechanisms.
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