Produção Nacional
Revisado por pares
Atividade de extratos de Arrabidaea chica (Humb. & Bonpl.) Verlot obtidos por processos biotecnológicos sobre a proliferação de fibroblastos e células tumorais humanas
2013; Brazilian Chemical Society; Volume: 36; Issue: 3 Linguagem: Inglês
10.1590/s0100-40422013000300014
ISSN1678-7064
AutoresDenise Taffarello, Michelle Pedroza Jorge, Ilza Maria de Oliveira Sousa, Marta Cristina Teixeira Duarte, Glyn Mara Figueira, Núbia de Cássia Almeida Queiroz, Rodney Alexandre Ferreira Rodrigues, João Ernesto de Carvalho, Ana Lúcia Tasca Góis Ruiz, Mary Ann Foglio, José M. Riveros, Marcos N. Eberlin, Elaine Cristina Cabral,
Tópico(s)Phytochemistry Medicinal Plant Applications
ResumoHUMAN TUMOR CELLS.Arrabidaea chica (H&B) Verlot is a plant popularly known as Pariri and this species is a known source of anthocyanins, flavonoids and tannins.This report describes an approach involving enzymatic treatment prior to extraction procedures to enhance A chica crude extract anticancer activity.Anticancer activity in human cancer cell lines in vitro using a 48 h SRB cell viability assay was performed to determine growth inhibition and cytotoxic properties.The final extraction yield without enzyme treatment was higher (24.28%) compared to the enzyme-treated material (19.03%), with an enhanced aglycones anthocyanin ratio as determined by HPLC-DAD and LC-MS with direct infusion.
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