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Double blind study of a Valerian preparation

1989; Elsevier BV; Volume: 32; Issue: 4 Linguagem: Inglês

10.1016/0091-3057(89)90082-8

1873-5177

Olov Lindahl, Lars Lindwall,

Phytochemistry and Biological Activities

Valerian root contains two substances of special pharmacological interest--valepotriates and sesquiterpenes. The former, which has been used for standardization of the drug, is cytotoxic. The latter has no such effect. Both have sedative effects. A double blind test has been carried out on a preparation (VALERINA NATT) containing primarily sesquiterpenes. When compared with placebo it showed a good and significant effect on poor sleep (p less than 0.001). Forty-four percent reported perfect sleep and 89% reported improved sleep from the preparation. No side effects were observed.