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Multifunctional Silver‐Embedded Magnetic Nanoparticles as SERS Nanoprobes and Their Applications

2009; Wiley; Volume: 6; Issue: 1 Linguagem: Inglês

10.1002/smll.200901459

1613-6829

Bong‐Hyun Jun, Mi Suk Noh, Jaeyun Kim, Gunsung Kim, Homan Kang, Min‐Soo Kim, Young‐Tae Seo, Jongho Baek, Jong‐Ho Kim, Ju‐Young Park, Seong-Yong Kim, Yong‐Kweon Kim, Taeghwan Hyeon, Myung‐Haing Cho, Dae Hong Jeong, Jeong Yong Lee,

Biosensors and Analytical Detection

In this study, surface-enhanced Raman spectroscopy (SERS)-encoded magnetic nanoparticles (NPs) are prepared and utilized as a multifunctional tagging material for cancer-cell targeting and separation. First, silver-embedded magnetic NPs are prepared, composed of an 18-nm magnetic core and a 16-nm-thick silica shell with silver NPs formed on the surface. After simple aromatic compounds are adsorbed on the silver-embedded magnetic NPs, they are coated with silica to provide them with chemical and physical stability. The resulting silica-encapsulated magnetic NPs (M-SERS dots) produce strong SERS signals and have magnetic properties. In a model application as a tagging material, the M-SERS dots are successfully utilized for targeting breast-cancer cells (SKBR3) and floating leukemia cells (SP2/O). The targeted cancer cells can be easily separated from the untargeted cells using an external magnetic field. The separated targeted cancer cells exhibit a Raman signal originating from the M-SERS dots. This system proves to be an efficient tool for separating targeted cells. Additionally, the magnetic-field-induced hot spots, which can provide a 1000-times-stronger SERS intensity due to aggregation of the NPs, are studied.