Acortatarins A and B, Two Novel Antioxidative Spiroalkaloids with a Naturally Unusual Morpholine Motif from Acorus tatarinowii
2010; American Chemical Society; Volume: 12; Issue: 8 Linguagem: Inglês
10.1021/ol100451p
ISSN1523-7060
AutoresXiaogang Tong, Lili Zhou, Yue‐Hu Wang, Chengfeng Xia, Ye Wang, Min Liang, Fan Fan Hou, Yong‐Xian Cheng,
Tópico(s)Computational Drug Discovery Methods
ResumoAcortatarins A (1) and B (2), two novel spiroalkaloids with a naturally unusual morpholine motif, were isolated from the rhizome of Acorus tatarinowii. Their structures with absolute configuration were determined by spectroscopic methods, X-ray diffraction analysis, and Mosher's method. Importantly, compound 1 could significantly inhibit reactive oxygen species production in high-glucose-stimulated mesangial cells in a dose- and time-dependent manner.
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