Functional architecture of the nucleus: organizing the regulatory machinery for gene expression, replication and repair
2003; Elsevier BV; Volume: 13; Issue: 11 Linguagem: Inglês
10.1016/j.tcb.2003.09.009
ISSN1879-3088
AutoresGary S. Stein, Sayyed K. Zaidi, Corey Braastad, Martı́n Montecino, André J. van Wijnen, Je‐Yong Choi, Janet L. Stein, Jane B. Lian, Amjad Javed,
Tópico(s)DNA Repair Mechanisms
ResumoThe organization and sorting of regulatory information for transcription, replication and repair depends on components of nuclear architecture. It is necessary, therefore, to understand cellular processes within the context of intranuclear microenvironments that mediate the focal assembly of the machinery for transcription, replication and repair and which facilitate the orchestration of these essential processes. Here, we discuss how nuclear anatomy supports the temporal and spatial coordination of regulatory protein recruitment for combinatorial control.
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