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Smoking and intermediate alpha1-antitrypsin deficiency and lung function in middle-aged men.

1977; BMJ; Volume: 2; Issue: 6092 Linguagem: Inglês

10.1136/bmj.2.6092.922

0959-8138

Christer Larsson, Sten Eriksson, H Dirksen,

Science and Education Research

Lung function was evaluated in a representative population sample of 50-year-0ld men living in one Swedish city. Twenty-four smoking and 15 non-smoking men heterozygous for alpha1-antitrypsin deficiency--that is, with the protease-inhibitor (Pi1 phenotype MZ--were carefully matched for weight and smoking habit with Pi M controls. The pulmonary function of non-smoking Pi MZ subjects did not differ from that of non-smoking Pi M controls. In contrast, smoking heterozygotes showed a significant loss of elastic recoil, enlarged residual volumes, and increased closing capacity but no signs of obstructive ventilatory impairment. Most smoking Pi MZ individuals reported mild exertional dyspnoea.