Neolacto (Type‐2 Chain)‐Sialoautoantigens Recognized by Human Cold Agglutinins
1990; Wiley; Volume: 59; Issue: 4 Linguagem: Inglês
10.1111/j.1423-0410.1990.tb00244.x
ISSN1423-0410
AutoresD. Roelcke, U R Hengge, Michael Kirschfink,
Tópico(s)Erythrocyte Function and Pathophysiology
ResumoAbstract The antigens Fl and Vo, recognized by cold agglutinins, are protease‐resistant differentiation antigens like I and i antigens. In contrast to Ii, Fl and Vo are sialidase‐susceptible antigens like the protease‐resistant Gd antigens. Because I/i antigens are branched/linear type‐2 (poly‐N‐acetyllactosamine or neolacto series) chains which are cleaved from red cells by endo‐β‐galactosidase, the effect of the enzyme on Fl, Vo and Gd antigens was studied. Fl and Gd antigens, previously shown to be sialylated branched (Fl), and linear and branched (Gd) type‐2 sequences, were not inactivated on red cells by the enzyme, whereas Vo antigenicity was completely abolished. The data suggest that Vo antigen is expressed on sialylated linear poly‐N‐acetyllactosamine sequences.
Referência(s)