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Reassessment of the role of CD8+ T cells in the induction of allograft tolerance by donor-specific blood transfusion

1999; Wiley; Volume: 29; Issue: 6 Linguagem: Inglês

10.1002/(sici)1521-4141(199906)29

1521-4141

Patrice Douillard, Caroline Vignes, Régis Josien, Elise Chiffoleau, Jean-Marie Heslan, Valia Proust, Jean‐Paul Soulillou, Maria Cristina Cuturi,

Hematopoietic Stem Cell Transplantation

European Journal of ImmunologyVolume 29, Issue 6 p. 1919-1924 ArticleFree Access Reassessment of the role of CD8+ T cells in the induction of allograft tolerance by donor-specific blood transfusion Patrice Douillard, Patrice Douillard INSERM Unité U 437 Immunointervention dans les allo- et xeno-transplantations and Institut de Transplantation et de Recherche en Transplantation (ITERT), Nantes, FranceSearch for more papers by this authorCaroline Vignes, Caroline Vignes INSERM Unité U 437 Immunointervention dans les allo- et xeno-transplantations and Institut de Transplantation et de Recherche en Transplantation (ITERT), Nantes, FranceSearch for more papers by this authorRégis Josien, Régis Josien INSERM Unité U 437 Immunointervention dans les allo- et xeno-transplantations and Institut de Transplantation et de Recherche en Transplantation (ITERT), Nantes, FranceSearch for more papers by this authorElise Chiffoleau, Elise Chiffoleau INSERM Unité U 437 Immunointervention dans les allo- et xeno-transplantations and Institut de Transplantation et de Recherche en Transplantation (ITERT), Nantes, FranceSearch for more papers by this authorJean-Marie Heslan, Jean-Marie Heslan INSERM Unité U 437 Immunointervention dans les allo- et xeno-transplantations and Institut de Transplantation et de Recherche en Transplantation (ITERT), Nantes, FranceSearch for more papers by this authorValia Proust, Valia Proust INSERM Unité U 437 Immunointervention dans les allo- et xeno-transplantations and Institut de Transplantation et de Recherche en Transplantation (ITERT), Nantes, FranceSearch for more papers by this authorJean-Paul Soulillou, Jean-Paul Soulillou INSERM Unité U 437 Immunointervention dans les allo- et xeno-transplantations and Institut de Transplantation et de Recherche en Transplantation (ITERT), Nantes, FranceSearch for more papers by this authorMaria Cristina Cuturi, Corresponding Author Maria Cristina Cuturi ccuturi@nantes.inserm.fr INSERM Unité U 437 Immunointervention dans les allo- et xeno-transplantations and Institut de Transplantation et de Recherche en Transplantation (ITERT), Nantes, FranceINSERM U437, Immeuble Jean Monnet, 30 bd Jean Monnet, F-44093 Nantes Cedex 1, France Fax: +33.240.08.74.11Search for more papers by this author Patrice Douillard, Patrice Douillard INSERM Unité U 437 Immunointervention dans les allo- et xeno-transplantations and Institut de Transplantation et de Recherche en Transplantation (ITERT), Nantes, FranceSearch for more papers by this authorCaroline Vignes, Caroline Vignes INSERM Unité U 437 Immunointervention dans les allo- et xeno-transplantations and Institut de Transplantation et de Recherche en Transplantation (ITERT), Nantes, FranceSearch for more papers by this authorRégis Josien, Régis Josien INSERM Unité U 437 Immunointervention dans les allo- et xeno-transplantations and Institut de Transplantation et de Recherche en Transplantation (ITERT), Nantes, FranceSearch for more papers by this authorElise Chiffoleau, Elise Chiffoleau INSERM Unité U 437 Immunointervention dans les allo- et xeno-transplantations and Institut de Transplantation et de Recherche en Transplantation (ITERT), Nantes, FranceSearch for more papers by this authorJean-Marie Heslan, Jean-Marie Heslan INSERM Unité U 437 Immunointervention dans les allo- et xeno-transplantations and Institut de Transplantation et de Recherche en Transplantation (ITERT), Nantes, FranceSearch for more papers by this authorValia Proust, Valia Proust INSERM Unité U 437 Immunointervention dans les allo- et xeno-transplantations and Institut de Transplantation et de Recherche en Transplantation (ITERT), Nantes, FranceSearch for more papers by this authorJean-Paul Soulillou, Jean-Paul Soulillou INSERM Unité U 437 Immunointervention dans les allo- et xeno-transplantations and Institut de Transplantation et de Recherche en Transplantation (ITERT), Nantes, FranceSearch for more papers by this authorMaria Cristina Cuturi, Corresponding Author Maria Cristina Cuturi ccuturi@nantes.inserm.fr INSERM Unité U 437 Immunointervention dans les allo- et xeno-transplantations and Institut de Transplantation et de Recherche en Transplantation (ITERT), Nantes, FranceINSERM U437, Immeuble Jean Monnet, 30 bd Jean Monnet, F-44093 Nantes Cedex 1, France Fax: +33.240.08.74.11Search for more papers by this author First published: 28 March 2006 https://doi.org/10.1002/(SICI)1521-4141(199906)29:06 3.0.CO;2-8Citations: 24AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Donor-specific allograft tolerance can be induced in adult rats by pregraft donor-specific blood transfusion (DST). We have previously shown that DST elicits in recipients the expansion of a donor-specific CD8+ T cell clone displaying the Vβ18-Dβ1-Jβ2.7 TCR rearrangement, which rapidly infiltrates allografts after transplantation, suggesting a regulatory function for this clone in DST-induced tolerance. In this study, recipients were pretreated before grafting, using an anti-CD8 monoclonal antibody to deplete CD8+ T cells. CD8 depletion before DST and transplantation abrogated allograft tolerance, and the CD8+ T cell clone was absent from allografts. These effects were not observed when CD8 depletion was performed after DST but before transplantation. We conclude that CD8+ T cells play a role in the induction of allograft tolerance by DST. Citing Literature Volume29, Issue6June 1999Pages 1919-1924 ReferencesRelatedInformation