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Neutropenia due to beta lactamine antibodies.

1983; BMJ; Volume: 287; Issue: 6408 Linguagem: Inglês

10.1136/bmj.287.6408.1832

0959-8138

B Rouveix, Kaı̈ss Lassoued, Daniel Vittecoq, B. Régnier,

Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Neutropenia developed in 13 patients during treatment with beta lactamines. The time of onset ranged from eight to 27 days after beginning treatment and occurred with doses as low as 40 mg/24 hours. Concomitant symptoms were eosinophilia, rashes, and fever. Leucoagglutinins were detected in eight out of nine patients by the microleucoagglutination technique. Clinical and serological findings suggested that neutrophils become sensitised as a result of absorption on the cell membrane of drug-antibody immune complexes. An immune mediated pathogenesis for neutropenia induced by beta lactamine seems highly probable.