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667 Effects of bariatric surgery (FOBI-CAPELLA) in non-alcoholic fatty liver disease: Study after 2 years

2006; Elsevier BV; Volume: 44; Linguagem: Inglês

10.1016/s0168-8278(06)80667-7

1600-0641

Carlos K Furuya, C.P.M.S. Oliveira, Evandro Sobroza de Mello, Jacob J. Faintuch, A. Rascovski, D.C.P. Vezzozo, Alfredo Halpern, Michio Matsuda, B Zilberstein, V.A.E. Alves, E.J. Carrilho,

Bariatric Surgery and Outcomes

Background and Aim: Mechanisms controlling iron metabolism are complex and involve several genes that may cause different kinds of primary iron overload.There are however unexplained types of iron overload and there is evidence that genetic background can modulate iron loading in mouse models.We evaluated the frequency and interactions of some genetic polymorphisms in patients with unexplained iron overload.Subjects and Methods: We studied 109 unrelated patients with hepatic iron overload established by liver biopsy or SQUID.C282Y homozygotes, C282Y/H63D compound heterozygotes and patients with secondary iron overload were excluded.We compared data with those of 161 healthy controls with normal serum iron indices.HFE (C282Y and H63D) and SLC40A1 [(CGG)7 9 microsatellite at 51-UTR] polymorphisms were analysed.Results: The distribution of HFE alleles and genotypes differed between patients and controls (p 45%) than in patients with normal low transferrin saturation (16.7% vs 2.7% and 50% vs 24.6%, respectively, p <0.01) with a significant interaction between H/D and [(CGG)8/8 9] genotypes. Conclusion:In patients with unexplained iron overload, the distribution of HFE and SLC40A1 polymorphisms differed compared to healthy controls.We suggest that these polymorphisms can interact together and may represent components of the genetic background favouring the development of iron overload in humans.