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The risk of cardiovascular disease associated with proteinuria in renal transplant patients

2002; Wolters Kluwer; Volume: 73; Issue: 8 Linguagem: Inglês

10.1097/00007890-200204270-00028

1534-6080

Gema Fern ndez-Fresnedo, R Escallada, Emilio Rodrigo, Ángel Francisco, J.G Cotorruelo, Saturnino Sanz de Castro, J.A Zubimendi, Juan Carlos Ruiz, Manuel Arias,

Organ Transplantation Techniques and Outcomes

Proteinuria in the general population has been shown to be associated with cardiovascular disease, which is the main cause of death in renal transplantation. We investigated the effect of proteinuria on cardiovascular disease after renal transplantation in 532 renal transplant patients with functioning grafts for more than 1 year. Patients were classified into two groups depending on the presence of persistent proteinuria. We analyzed graft and patient survival, posttransplantation cardiovascular disease, and main causes of graft loss and death. Five- and 10-year graft and patient survival rates were lower in the group with proteinuria. The main cause of death was vascular disease in both groups. The presence of posttransplantation cardiovascular disease was higher in the group with proteinuria. Persistent proteinuria was associated with graft loss (RR=4.18), patient death (RR=1.92), and cardiovascular disease (RR=2.45). In conclusion, persistent proteinuria was an independent risk factor for increased cardiovascular morbidity and mortality in renal transplant patients.