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BIBTEX RIS

Room Temperature Cross-Coupling of Highly Functionalized Organozinc Reagents with Thiomethylated N -Heterocycles by Nickel Catalysis

2010; American Chemical Society; Volume: 75; Issue: 6 Linguagem: Inglês

10.1021/jo1001615

ISSN

1520-6904

Autores

Laurin Melzig, Albrecht Metzger, Paul Knochel,

Tópico(s)

Cyclopropane Reaction Mechanisms

Resumo

A variety of thiomethyl-substituted N-heterocycles such as pyridines, isoquinolines, pyrimidines, pyrazines, pyridazines, quinazolines, triazines, benzothiazoles, or benzoxazoles undergo smooth Ni-catalyzed cross-coupling reactions with functionalized aryl-, heteroaryl-, alkyl-, and benzylic zinc reagents using an inexpensive Ni(acac)2/DPE-Phos catalytic system at 25 °C.

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