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Overexpression of chromatin assembly factor‐1 (CAF‐1) p60 is predictive of adverse behaviour of prostatic cancer

2009; Wiley; Volume: 54; Issue: 5 Linguagem: Inglês

10.1111/j.1365-2559.2009.03266.x

1365-2559

Stefania Staibano, Massimo Mascolo, Francesco Paolo Mancini, Annamaria Kisslinger, Gaetano Salvatore, Maria Benedetto, Paolo Chieffi, Vincenzo Altieri, Domenico Prezioso, Gennaro Ilardi, Gaetano De Rosa, Donatella Tramontano,

Cancer, Lipids, and Metabolism

Prostatic cancer may remain organ-confined indefinitely; in a number of patients, however it gives rise to clinical symptoms and death. The biological behaviour of this tumour mostly remains difficult to predict. A promising tool for diagnosis and prognosis of some human tumours is the chromatin assembly factor-1 (CAF-1), involved in the control of higher order chromatin organization. The aim was to explore the role of CAF-1/p60 protein as a new prognostic marker for prostatic cancer.The expression of CAF-1/p60 was evaluated by immunohistochemistry and Western blotting in a selected series of prostatic cancers and in prostatic cancer cell lines. Results were compared with clinicopathological data and outcome of patients. CAF-1/p60 was expressed in all cases, with a linear increase from low-grade tumours (Gleason score 7). By comparing results with follow-up data, a significant association between overexpression of CAF-1/p60 and unfavourable behaviour of prostatic cancer emerged, and its predictive value was independent of classical prognostic factors.In our series of cases, overexpression of CAF-1/p60 characterized prostatic cancers with a worse prognosis. CAF-1/p60 has a potential role as a new reliable prognostic biomarker for prostatic cancer.