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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Genetic polymorphisms in the tumour necrosis factor locus in childhood acute lymphoblastic leukaemia

2002; Wiley; Volume: 119; Issue: 4 Linguagem: Inglês

10.1046/j.1365-2141.2002.03964.x

ISSN

1365-2141

Autores

Seisho Takeuchi, Naoko Takeuchi, Kunihiro Tsukasaki, Claus R. Bartram, Martin Zimmermann, Martin Schrappe, Hirokuni Taguchi, H. Phillip Koeffler,

Tópico(s)

Lung Cancer Research Studies

Resumo

Summary. Genetic polymorphisms in the tumour necrosis factor (TNF) locus influence the outcome of non‐Hodgkin's lymphoma (NHL). We investigated whether these polymorphisms might contribute to the clinical course of childhood acute lymphoblastic leukaemia (ALL). Genomic DNA from 214 childhood ALL patients was analysed. Patients with a high‐risk haplotype were older than patients with low‐risk haplotype ( P = 0·024). No statistically significant associations were found between TNF haplotype and sex, WBC counts, central nervous system involvement, immunophenotype, response to chemotherapy, and event‐free survival. These data suggest that genetic polymorphisms in the TNF locus have a limited effect on the outcome of childhood ALL.

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