Naïve and Memory CD4 + T Cell Survival Controlled by Clonal Abundance
2006; American Association for the Advancement of Science; Volume: 312; Issue: 5770 Linguagem: Inglês
10.1126/science.1124228
ISSN1095-9203
AutoresJason Hataye, James Moon, Alexander Khoruts, Cavan Reilly, Marc K. Jenkins,
Tópico(s)Immunotherapy and Immune Responses
ResumoImmunity to a plethora of microbes depends on a diverse repertoire of naïve lymphocytes and the production of long-lived memory cells. We present evidence here that low clonal abundance in a polyclonal repertoire favors the survival and activation of naïve CD4 + T cells as well as the survival of their memory cell progeny. The inverse relation between clonal frequency and survival suggests that intraclonal competition could help maintain an optimally diverse repertoire of T cells and an optimal environment for the generation of long-lived memory cells.
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