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Increased mortality from chronic liver disease and cirrhosis 13 years after the Taiwan ?yucheng? (?oil disease?) incident

1997; Wiley; Volume: 31; Issue: 2 Linguagem: Inglês

10.1002/(sici)1097-0274(199702)31

1097-0274

Mei‐Lin Yu, Yue Leon Guo, Chen‐Chin Hsu, Walter J. Rogan,

Pesticide Exposure and Toxicity

American Journal of Industrial MedicineVolume 31, Issue 2 p. 172-175 Increased mortality from chronic liver disease and cirrhosis 13 years after the Taiwan "yucheng" ("oil disease") incident Mei-Lin Yu MD, DrPh, Mei-Lin Yu MD, DrPh Department of Public Health, National Cheng Kung University Medical College, Tainan, TaiwanSearch for more papers by this authorYueliang Leon Guo MD, PhD, Corresponding Author Yueliang Leon Guo MD, PhD Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, TaiwanNational Cheng Kung University Medical College, Department of Environmental and Occupational Health, 38 Sheng Li Road, Tainan 70428, Taiwan, ROCSearch for more papers by this authorChen-Chin Hsu MD, PhD, Chen-Chin Hsu MD, PhD Department of Psychiatry, Tainan City Hospital, Tainan, TaiwanSearch for more papers by this authorWalter J. Rogan MD, Walter J. Rogan MD Office of Clinical Research, National Institute of Environmental Health Sciences, Research Triangle Park, NCSearch for more papers by this author Mei-Lin Yu MD, DrPh, Mei-Lin Yu MD, DrPh Department of Public Health, National Cheng Kung University Medical College, Tainan, TaiwanSearch for more papers by this authorYueliang Leon Guo MD, PhD, Corresponding Author Yueliang Leon Guo MD, PhD Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, TaiwanNational Cheng Kung University Medical College, Department of Environmental and Occupational Health, 38 Sheng Li Road, Tainan 70428, Taiwan, ROCSearch for more papers by this authorChen-Chin Hsu MD, PhD, Chen-Chin Hsu MD, PhD Department of Psychiatry, Tainan City Hospital, Tainan, TaiwanSearch for more papers by this authorWalter J. Rogan MD, Walter J. Rogan MD Office of Clinical Research, National Institute of Environmental Health Sciences, Research Triangle Park, NCSearch for more papers by this author First published: 06 December 1998 https://doi.org/10.1002/(SICI)1097-0274(199702)31:2 3.0.CO;2-1Citations: 32AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract In 1979, a mass poisoning involving some 2,000 persons occurred in central Taiwan from cooking oil contaminated by polychlorinated biphenyls (PCBs) and their heat-degraded byproducts, including polychlorinated dibenzofurans (PCDFs). The responsible health department registered cases for clinical purposes between 1979 and 1983. The exposed persons are referred to as the "yucheng" (oil disease) cohort. PCBs and PCDFs are toxic chemicals widely dispersed in the environment and in human tissue, which persist long after exposure. The consequences of exposure to these agents are not well understood. We traced the cohort through December 31, 1991, and compared overall and cause-specific mortality of 1,837 "yucheng" subjects with age, gender, and calendar time-specific mortality rates for the Taiwan general population. Eighty-three deaths were identified from 23,404 observed person-years. Even though the overall standardized mortality ratio (SMR) was 0.8 (95% confidence interval (CI) 0.7–1.0), there was a substantial elevation in the mortality rate for chronic liver disease and cirrhosis (10 deaths, SMR = 2.7, 95% CI = 1.3–4.9). Mortality from malignant neoplasms and other causes was not significantly different from that of the Taiwan population. PCB/PCDF exposure appears to promote the development of severe liver disease, perhaps in combination with known risk factors such as infection with hepatitis B virus. Further follow-up of this young cohort is necessary to see if the consequences include hepatic cancer. Am. J. Ind. Med. 31:172–175, 1997. © Wiley-Liss, Inc. References Anderson HA (1989): General population exposure to environmental concentrations of halogenated biphenyls. In RD Kimbrough, AA Jensen (eds): " Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products," 2nd fully revised ed. Amsterdam: Elsevier, pp. 325–344. 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