Accelerating lead optimization of chromone carboxamide scaffold throughout microwave-assisted organic synthesis
2011; Elsevier BV; Volume: 52; Issue: 48 Linguagem: Inglês
10.1016/j.tetlet.2011.09.095
ISSN1873-3581
AutoresFernando Cagide, Joana Reis, Alexandra Gaspar, Fernanda Borges,
Tópico(s)Chemical Synthesis and Analysis
ResumoMicrowave irradiation offers a considerable advantage over conventional synthesis with rate enhancements and cleaner reactions. Accordingly, a new microwave-assisted method for the synthesis of functionalized chromones was developed allowing the obtention of a library of chromone carboxamides. The method has been shown to present several advantages including operational simplicity, good performance, significant reduction in reaction time, less formation of by-products, and easier work-up.
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