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Use of Continuous Subcutaneous Growth Hormone‐Releasing Hormone (GHRH (1–29)NH 2 ) Infusions to Augment Growth Hormone Secretion and to Promote Growth

1989; Wiley; Volume: 78; Issue: s349 Linguagem: Inglês

10.1111/j.1651-2227.1989.tb17180.x

1651-2227

Caroline Brain, Peter C. Hindmarsh, P J Pringle, C G D Brook,

Growth Hormone and Insulin-like Growth Factors

ABSTRACT. Brain, C., Hindmarsh, P.C., Pringle, P.J. and Brook, C.G.D. (Endocrine Unit, the Middlesex Hospital, London, UK). Use of continuous subcutaneous growth hormone‐releasing hormone (GHRH (1–29)NH 2 ) infusions to augment growth hormone secretion and to promote growth. Acta Paediatr Scand [Suppl] 349: 109, 1989. It has previously been shown that an 8‐day continuous subcutaneous infusion of GHRH (1–29)NH 2 in adult males augments growth hormone (GH) secretion with no evidence of desensitization of the response. The present report details the results of treatment with continuous subcutaneous infusions of CHRH (1–29)NH 2 in eight children aged 6–9 years with partial GH insufficiency. All the children showed augmentation of GH secretion and an increase in growth velocity after 3 and 6 months of therapy.