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BIBTEX RIS

Chronic endothelin-1 infusion elevates glomerular sieving coefficient and proximal tubular albumin reuptake in the rat

2012; Elsevier BV; Volume: 91; Issue: 13-14 Linguagem: Inglês

10.1016/j.lfs.2012.06.007

ISSN

1879-0631

Autores

Mohamed A. Saleh, Ruben M. Sandoval, George Rhodes, Silvia B. Campos-Bilderback, Bruce A. Molitoris, David M. Pollock,

Tópico(s)

Ion Transport and Channel Regulation

Resumo

We have previously found that chronic endothelin-1 (ET-1) infusion in Sprague-Dawley rats increases glomerular permeability to albumin (P(alb)) as assessed in vitro independent of blood pressure with no observed albuminuria. In this study, we hypothesized that ET-1 increases glomerular albumin filtration with accompanied increase in albumin uptake via the proximal tubule, which masks the expected increase in urinary albumin excretion.

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