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A New Asymmetric Synthesis of the Anti-Tumor Alkaloid ( R )-(+)-Crispine A

2007; American Chemical Society; Volume: 72; Issue: 23 Linguagem: Inglês

10.1021/jo071235x

1520-6904

Steven M. Allin, Sean N. Gaskell, Joannah M. R. Towler, Philip C. Bulman Page, Basudeb Saha, Michael J. McKenzie, William P. Martin,

Advanced Synthetic Organic Chemistry

We report a novel, facile, and asymmetric approach for the synthesis of the anti-tumor alkaloid (+)-crispine A via a highly diastereoselective N-acyliminium cyclization reaction as a key synthetic step.