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Tyrosine kinases: modular signaling enzymes with tunable specificities

1995; Elsevier BV; Volume: 2; Issue: 8 Linguagem: Inglês

10.1016/1074-5521(95)90183-3

1879-1301

Kevan M. Shokat,

Protein Tyrosine Phosphatases

Cytoplasmic tyrosine kinases are composed of modular domains; one (SH1) has catalytic activity, the other two (SH2 and SH3) do not. Kinase specificity is largely determined by the binding preferences of the SH2 domain. Attaching the SH1 domain to a new SH2 domain, via protein-protein association or mutation, can thus dramatically change kinase function.