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Regional dissociation of histidyl-proline diketopiperazine (cyclo-(His-Pro)) and thyrotropin-releasing hormone (TRH) in the rat brain

1982; Elsevier BV; Volume: 231; Issue: 2 Linguagem: Inglês

10.1016/0006-8993(82)90382-1

1872-6240

Masatomo Mori, Chandan Prasad, John F. Wilber,

Nitric Oxide and Endothelin Effects

The concentrations of cyclo-(His-Pro) and its precursor, thyrotropin-releasing hormone (TRH) were measured in seven different areas of rat brain using specific radioimmunoassays. Although the concentration of both of these peptides was highest in the hypothalamus, their distribution patterns in all other loci of the brain were dissimilar. These results suggest that factors in addition to TRH concentrations are important in determining the unique concentration pattern of cyclo-(His-Pro) in the brain.