Participation of leukocyte function-associated antigen-1 and NK cells in the homing of thymic CD8+NKT cells to the liver
2000; Wiley; Volume: 30; Issue: 10 Linguagem: Inglês
10.1002/1521-4141(200010)30
ISSN1521-4141
AutoresMasashi Emoto, Mamiko Miyamoto, Kenji Namba, Rudolf Schmits, Nico van Rooijen, Eiji Kita, Stefan H. E. Kaufmann,
Tópico(s)Immunotherapy and Immune Responses
ResumoEuropean Journal of ImmunologyVolume 30, Issue 10 p. 3049-3056 ArticleFree Access Participation of leukocyte function-associated antigen-1 and NK cells in the homing of thymic CD8+NKT cells to the liver Masashi Emoto, Masashi Emoto Department of Immunology, Max-Planck-Institute for Infection Biology, Berlin, GermanySearch for more papers by this authorMamiko Miyamoto, Mamiko Miyamoto Department of Immunology, Max-Planck-Institute for Infection Biology, Berlin, GermanySearch for more papers by this authorKenji Namba, Kenji Namba Department of Immunology, Max-Planck-Institute for Infection Biology, Berlin, Germany New Product Research Laboratories I, Daiichi Pharmaceutical Co., Ltd., Tokyo, JapanSearch for more papers by this authorRudolf Schmits, Rudolf Schmits Department of Internal Medicine, University of Saarland, Homburg, GermanySearch for more papers by this authorNico van Rooijen, Nico van Rooijen Department of Cell Biology and Immunology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The NetherlandsSearch for more papers by this authorEiji Kita, Eiji Kita Department of Bacteriology, Nara Medical University, Nara, JapanSearch for more papers by this authorStefan H. E. Kaufmann, Corresponding Author Stefan H. E. Kaufmann [email protected] Department of Immunology, Max-Planck-Institute for Infection Biology, Berlin, GermanyDepartment of Immunology, Max-Planck-Institute for Infection Biology, Schumannstrasse 21/22, D-10117 Berlin, Germany Fax: +49-30-28460-501Search for more papers by this author Masashi Emoto, Masashi Emoto Department of Immunology, Max-Planck-Institute for Infection Biology, Berlin, GermanySearch for more papers by this authorMamiko Miyamoto, Mamiko Miyamoto Department of Immunology, Max-Planck-Institute for Infection Biology, Berlin, GermanySearch for more papers by this authorKenji Namba, Kenji Namba Department of Immunology, Max-Planck-Institute for Infection Biology, Berlin, Germany New Product Research Laboratories I, Daiichi Pharmaceutical Co., Ltd., Tokyo, JapanSearch for more papers by this authorRudolf Schmits, Rudolf Schmits Department of Internal Medicine, University of Saarland, Homburg, GermanySearch for more papers by this authorNico van Rooijen, Nico van Rooijen Department of Cell Biology and Immunology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The NetherlandsSearch for more papers by this authorEiji Kita, Eiji Kita Department of Bacteriology, Nara Medical University, Nara, JapanSearch for more papers by this authorStefan H. E. Kaufmann, Corresponding Author Stefan H. E. Kaufmann [email protected] Department of Immunology, Max-Planck-Institute for Infection Biology, Berlin, GermanyDepartment of Immunology, Max-Planck-Institute for Infection Biology, Schumannstrasse 21/22, D-10117 Berlin, Germany Fax: +49-30-28460-501Search for more papers by this author First published: 29 November 2000 https://doi.org/10.1002/1521-4141(200010)30:10 3.0.CO;2-FCitations: 23 The first two authors contributed equally to this work. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract A distinct CD8+NKT cell population expressing TCRα/β or TCRγ/δ has been identified in liver and thymus. We wondered whether cell adhesion molecules play a role in the homing of CD8+NKT cells to the liver. The number of liver CD8+NKT cells was markedly reduced in leukocyte function-associated antigen (LFA)-1–/– mice compared with wild-type (WT) mice. The reduction was restricted to the liver only and no measurable alterations were found in other organs. In the liver of SCID mice reconstituted with thymocytes from LFA-1–/– or WT mice, the number of donor-derived CD8+NKT cells was comparable and the vast majority of these cells expressed TCRα/β. In a reciprocal radiation thymocyte reconstitution system with LFA-1–/– and WT mice, LFA-1 expressed on liver cells other than CD8+NKT cells appeared to be required for the homing of thymic CD8+NKT cells to the liver. 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