New syntheses of α-amino acids based on n-acylimino acetates
1988; Elsevier BV; Volume: 44; Issue: 17 Linguagem: Inglês
10.1016/s0040-4020(01)86046-4
ISSN1464-5416
AutoresThomas Bretschneider, Wolfgang Miltz, Peter Münster, Wölfgang Steglich,
Tópico(s)Synthesis and Characterization of Heterocyclic Compounds
ResumoThe reaction of N-acylamino-2-bromoacetes 2 (via N-acylimino acetates 3) with higher order mixed cuprates, trimethysilyl enol ether and β-dicarbonyl compounds leads to a variety of α-amino acid derivatives. Their conversion into the free amino acids can be conveniently carried out by the use of t-butyl protection. In case of the N-acetyl compounds cleavage of the protecting group and optical resolution can be achieved in one step by hog renal acylase.
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