Prednisone and azathioprine compared to prednisone plus low-dose azathioprine and cyclophosphamide in the treatment of diffuse lupus nephritis
1976; Wiley; Volume: 19; Issue: 4 Linguagem: Inglês
10.1002/1529-0131(197607/08)19
ISSN1529-0131
AutoresEllen M. Ginzler, Herbert S. Diamond, Maria Guttadauria, David S. Kaplan,
Tópico(s)Cytokine Signaling Pathways and Interactions
ResumoA 1-year double-blind crossover study comparing prednisone and azathioprine to prednisone plus low-dose azathioprine and cyclophosphamide was carried out in 14 patients with diffuse lupus nephritis. Low-dose triple therapy had no apparent therapeutic advantage over prednisone plus azathioprine. Cyclophosphamide-induced ovarian failure and hematuria were not avoided by its use in low dose.
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