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Evaluation of the Health Utilities Index Mark-3 in Heart Failure

2010; Elsevier BV; Volume: 17; Issue: 2 Linguagem: Inglês

10.1016/j.cardfail.2010.08.014

1532-8414

Susan J. Pressler, George J. Eckert, Gwendolyn C. Morrison, Michael D. Murray, Neil Oldridge,

Heart Failure Treatment and Management

Background The purpose of this study was to evaluate the reliability, validity, and responsiveness to change of the Health Utilities Index Mark-3 (HUI-3) in heart failure (HF) for use in cost-effectiveness studies. Methods and Results Two hundred eleven patients with HF recruited from outpatient clinics were enrolled; 165 completed the 26-week study. Patients completed 4 health-related quality of life questionnaires (baseline and 4, 8, and 26 weeks), including the HUI-3, the Medical Outcomes Study Short-form 12 (SF-12), the Minnesota Living with Heart Failure Questionnaire (LHFQ), and the Chronic Heart Failure Questionnaire (CHQ). The HUI-3 indicated moderate or fair health-related quality of life overall; the attributes most impaired were pain, ambulation, cognition, and emotion. Internal consistency reliability (Cronbach's alpha = 0.51) was low and test-retest reliability (intraclass correlation coefficient = 0.68) was adequate. The HUI-3 total score was significantly associated with the SF-12, LHFQ, and CHQ total scores. It discriminated among patients with varying New York Heart Association class (P < .001) and varying perceived health (P < .001). The HUI-3 was less responsive to perceived change in health condition than the LHFQ or the CHQ. Conclusions The HUI-3 demonstrated satisfactory reliability and validity in this sample supporting its use in cost-effectiveness studies.