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Identification and quantification of 2-amino-3,4,8-trimethylimidazo-[4,5- f ]quinoxaline (4,8-DiMeIQx) in beef extract

1985; Oxford University Press; Volume: 6; Issue: 10 Linguagem: Inglês

10.1093/carcin/6.10.1537

1460-2180

Makoto Takahashi, Keiji Wakabayashi, Minako Nagao, Ziro Yamaizumi, Shigeaki Sato, Naohide Kinae, Isao Tomita, Takashi Sügimura,

Synthesis and Biological Evaluation

2-Amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (4,8-DiMeIQx) was found in bacteriological-grade beef extract by liquid chromatographies with electrochemical detection and a photodiode array detector. 4,8-DiMeIQx was estimated to be present at a level of 10.0 ng per g of beef extract, and to account for 9% of the total mutagenicity of the extract.