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Induced neuronal expression of class I major histocompatibility complex mRNA in acute and chronic inflammation models

2002; Elsevier BV; Volume: 131; Issue: 1-2 Linguagem: Inglês

10.1016/s0165-5728(02)00258-8

1872-8421

Jane A. Foster, Ning Quan, Edra L Stern, Krister Kristensson, Miles Herkenham,

interferon and immune responses

Studies have demonstrated neuronal expression of class I major histocompatibility complex (MHC) mRNA and protein in normal and developing brain and in response to injury or viral infection. We report neuronal expression of class I MHC mRNA in hypothalamic paraventricular nucleus (PVN) neurons in rats following systemic infection with Trypanosoma brucei brucei parasites (chronic) and in response to intravenous 1 mg/kg lipopolysaccharide administration (acute peripheral) and in striatal neurons following intrastriatal 5 microg lipopolysaccharide injection (acute central). These results demonstrate that neurons can be a source of immune signaling molecules and establish class I MHC as part of the neuronal component of immune responses.