Synthesis, structural characterization and antitumor activity evaluations of copper complex with tetraazamacrocyclic ligand
1999; Elsevier BV; Volume: 9; Issue: 8 Linguagem: Inglês
10.1016/s0960-894x(99)00139-0
ISSN1464-3405
AutoresDeyuan Kong, Qin Chen, Linhua Meng, Yuyuan Xie,
Tópico(s)Click Chemistry and Applications
ResumoCu (II) complex with 1,4,7,10-tetrakis(2-cyanoethyl-)-1,4,7,10-tetraazacyclododecane was prepared and characterized by X-ray diffraction. Four nitrogen atoms of macrocyclic ligand and oxygen atom of water molecule defined a tetragonal pyramidal polyhedron surrounding the central copper atom. Preliminary pharmacological tests showed that it had antitumor activity against P388 and BEL-7404 cell lines in vitro. Also it exhibited perturbation effects to K562 tumor cell lines at G0-G1 stage and further studies showed that it can cleave supercoiled DNA (pBR 322) to nicked and linear DNA in aerobic condition.
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