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On the role of antidiuretic hormone in the inhibition of acute water diuresis in adrenal insufficiency and the effects of gluco- and mineralocorticoids in reversing the inhibition

1970; American Society for Clinical Investigation; Volume: 49; Issue: 9 Linguagem: Inglês

10.1172/jci106390

1558-8238

Howard H. Green, Avery R. Harrington, Heinz Valtin,

Adrenal Hormones and Disorders

In order to determine whether or not antidiuretic hormone (ADH) is essential to the inhibition of an acute water diuresis in adrenal insufficiency, the response to oral water loads was tested in rats with hereditary hypothalamic diabetes insipidus (DI) which lack ADH. It was found that 60 min after water loads of 3 or 5% of body weight urine flow was significantly lower and urine osmolality significantly higher in adrenalectomized DI rats than in the same DI rats before removal of their adrenal glands.