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Synthesis of nitrogen heterocycles via α-aminoalkyl radicals generated from α-silyl secondary amines under visible light irradiation

2014; Royal Society of Chemistry; Volume: 50; Issue: 64 Linguagem: Inglês

10.1039/c4cc03000a

1364-548X

Kazunari Nakajima, Mai Kitagawa, Yuya Ashida, Yoshihiro Miyake, Yoshiaki Nishibayashi,

Catalytic C–H Functionalization Methods

We have succeeded in the visible light-mediated synthetic use of α-aminoalkyl radicals derived from α-silyl secondary amines toward addition to α,β-unsaturated carbonyl compounds. The resulting γ-aminocarbonyl compounds are converted into γ-lactams and pyrroles in a one-pot process.