Toxicity, antimicrobial and antioxidant activities of methyl salicylate dominated essential oils of Laportea aestuans (Gaud)
2011; Elsevier BV; Volume: 9; Linguagem: Inglês
10.1016/j.arabjc.2011.09.019
ISSN1878-5379
Autores Tópico(s)Ethnobotanical and Medicinal Plants Studies
ResumoThe colourless essential oils obtained by hydro-distillation from the whole plant of Laportea aestuans (Gaud) were analysed by GC and GC/MS. The major constituents in the oil were methyl salicylate (54.50%), fenchol (10.59%), 1, 2-cyclohexanedione dioxime (9.40%), 1, 4-octadiene (8.86%) and linalool (3.26%). The toxicity results obtained from brine shrimp lethality test gave LC50 value of 367.1805 μg/ml indicating that the oil is toxic. The oils showed appreciable antimicrobial activity against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella typhi, Candida albicans, Rhizopus stolon, Aspergillus niger and Penicillium nonatum at 200 mg/ml when compared to standards; gentamicin for bacteria and tioconazole for fungi. The oil was however very active against the fungi R. stolon and A. niger at 25–200 mg/ml. While the in vitro antioxidant activities of the oils determined by scavenging effect on 2, 2-diphenyl-1-picryl hydrazyl radical method showed that the oils have promising antioxidant activity as a free radical scavenger. At 0.1 and 0.2 mg/ml, the % inhibition of the essential oil (84.46% and 86.87%, respectively) was discovered to be higher than the % inhibition of α-tocopherol (15.4% and 12.4%).
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