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Antifungal susceptibility profile of clinical Fusarium spp. isolates identified by molecular methods

2008; Oxford University Press; Volume: 61; Issue: 4 Linguagem: Inglês

10.1093/jac/dkn022

1460-2091

Ana Alastruey‐Izquierdo, Manuel Cuenca‐Estrella, Araceli Monzón, Emilia Mellado, J. L. Rodríguez-Tudela,

Mycorrhizal Fungi and Plant Interactions

To analyse the susceptibility pattern of a collection of Fusarium clinical isolates. The antifungal susceptibility pattern of 67 isolates of Fusarium was analysed. Strains were identified by morphological and molecular methods by means of sequencing elongation factor α. Six different species were identified. Fusarium solani was the most frequently isolated, followed by Fusarium oxysporum, Fusarium proliferatum and Fusarium verticilloides. Amphotericin B was the only drug with in vitro activity (range: 0.015–32 mg/L). The rest of the antifungals tested (itraconazole, voriconazole, ravuconazole, posaconazole and terbinafine) showed very poor activity against Fusarium, confirming the multiresistant nature of this genus.