The mass spectrometer as a gaschromatographic detector
1971; Elsevier BV; Volume: 34; Issue: 2 Linguagem: Inglês
10.1016/0009-8981(71)90168-9
ISSN1873-3492
AutoresC. J. W. Brooks, Brian S. Middleditch,
Tópico(s)Advanced Chemical Sensor Technologies
ResumoQualitative and quantitative aspects of mass spectrometry, as applied to gaschromatographic studies, are briefly discussed. Measurements of ion currents produced by electron impact, before separation in the magnetic sector, indicate that sensitivity factors are of the same order for many steroids. The utility of “single ion monitoring”, in which ions of one characteristic m/e value are selectively detected during chromatography, is illustrated with particular reference to estr-4-en-17β-ol and its 17α-ethynyl, 17α-ethyl and 17α-allyl analogues. The detector response is proportional to the amount of sample injected: data are given for the range 50–1000 pg. Selective detection of a particular estrenol is exemplified by results for chloromethyl(dimethyl)silyl ethers. The stationary phases OV-1 and Dexsil-300 GC are compared.
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