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Glycodendritic structures: tools to interact with DC-SIGN

2013; UNIVERSIDADE DE SÃO PAULO; Volume: 49; Issue: spe Linguagem: Inglês

10.1590/s1984-82502013000700009

2175-9790

José J. Reina, Javier Rojo,

Chemical Synthesis and Analysis

The key role of carbohydrates in many biological events has attracted the interest of the scientific community. This fact has demanded the access to new tools necessary to understand this role and the interaction of carbohydrates with their corresponding receptors, lectins. Glycodendrimers and glycodendritic structures in general, have demonstrated to be very efficient and interesting tools to intervene in those processes where carbohydrates participate. In this review, we discuss the different glycodendritic structures that have been used to interfere with DC-SIGN, a very attractive lectin involved in infection processes and in the regulation of the immune response.