Fungicidal activity of tioconazole in relation to growth phase of Candida albicans and Candida parapsilosis
1984; American Society for Microbiology; Volume: 26; Issue: 5 Linguagem: Inglês
10.1128/aac.26.5.699
ISSN1098-6596
Autores Tópico(s)Plant Pathogens and Fungal Diseases
ResumoIt was shown that tioconazole possesses an important property not shared by ketoconazole and miconazole, its well-known relatives in the imidazole group of antifungal drugs. At a concentration of 3.8 X 10(-5) M, tioconazole, like miconazole, caused rapid 2- to 3-log reductions in CFU per milliliter when added to late-logarithmic-phase Candida albicans or Candida parapsilosis cells. Only tioconazole, however, exerted similar reductions when added to diluted stationary-phase cultures. This growth-phase-independent lethal action has important clinical implications and may explain the superior performance of tioconazole, which was observed in earlier comparative drug studies.
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