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Hydroxyzine hydrochloride and methylphenidate hydrochloride in the management of enuresis

1962; Elsevier BV; Volume: 61; Issue: 3 Linguagem: Inglês

10.1016/s0022-3476(62)80376-x

1097-6833

E Breger,

Urinary Bladder and Prostate Research

This research focuses on the use of two new psychopharmacologic agents of widely separated structure and activity as part of a psychologically oriented program management of enuresis. After evaluation, 150 enuretic children, aged 5 to 14 years, were placed in three groups, one receiving hydroxyzine hydrochloride (a tranquilizer); another, methylphenidate hydrochloride (a stimulant); and the third, a placebo. All children received supportive and suggestive management over a 3 month period. There was a statistically significant difference in improvement between those children receiving active medication and those receiving a placebo. The total treatment plan effected cure or great improvement in 36 per cent of the children. An “abormal” history as defined in the text significantly impeded therapeutic response. The children over 10 years of age responded particularly poorly to this therapy. Improvement was not related to the child's sex, level of maladjustment and anxiety, or family history of enuresis. This research focuses on the use of two new psychopharmacologic agents of widely separated structure and activity as part of a psychologically oriented program management of enuresis. After evaluation, 150 enuretic children, aged 5 to 14 years, were placed in three groups, one receiving hydroxyzine hydrochloride (a tranquilizer); another, methylphenidate hydrochloride (a stimulant); and the third, a placebo. All children received supportive and suggestive management over a 3 month period. There was a statistically significant difference in improvement between those children receiving active medication and those receiving a placebo. The total treatment plan effected cure or great improvement in 36 per cent of the children. An “abormal” history as defined in the text significantly impeded therapeutic response. The children over 10 years of age responded particularly poorly to this therapy. Improvement was not related to the child's sex, level of maladjustment and anxiety, or family history of enuresis.